Candidiasis is the origin of several chronic diseases and causes a wide range of symptoms from mucosal to systemic and deadly infections. Vaginal patches are one of the best drug delivery systems for the treatment of fungal infections in the vaginal environment, so a mucoadhesive film containing drugs such as clotrimazole and metronidazole is commercially available for patients. In the present study, a physicochemical comparison is made between clotrimazole loaded film and nanofiber fabricated with the new hybrid mucoadhesive formulation of dextran and alginate. Toxicity testing was performed using the MTT assay. Bioadhesion and antifungal effects were investigated for fibers and films. The release behavior of clotrimazole from two systems was evaluated by Franz cell in each case. The most important difference between nanofibrous and film mats were obtained in antifungal, mucoadhesive, Young's modulus and morphology. The nanofiber has a higher antifungal effect and two-fold adhesive to the mouse tissue, than film. The inherent flexibility of nanofiber obviated the need for a plasticizer, which may have cytotoxic side effects. The Clotrimazole loaded nanofibrous of Alginate/Dextran mats were successfully electrospun. They exhibited more bioadhesive with higher and faster antifungal properties versus similar formulation film. Further in vivo investigation is required for their application in vaginal candidiasis.

念珠菌病它是几种慢性疾病的起源，并引起从粘膜到全身和致命感染的多种症状。阴道贴剂是用于治疗阴道环境中真菌感染的最佳药物输送系统之一，因此含有克霉唑和甲硝唑等药物的粘膜粘附膜可从市场上买到。在本研究中，对负载克霉唑的薄膜和使用新的葡聚糖和藻酸盐混合粘膜粘附剂制成的纳米纤维进行了理化比较。使用MTT测定法进行毒性测试。研究了纤维和薄膜的生物粘附和抗真菌作用。在每种情况下，均通过Franz细胞评估克霉唑从两个系统的释放行为。纳米纤维垫和薄膜垫之间最重要的区别在于抗真菌剂，粘膜粘附剂，杨氏模量和形态。与薄膜相比，纳米纤维具有更高的抗真菌作用和对小鼠组织的两倍粘合力。纳米纤维固有的柔韧性消除了对增塑剂的需求，增塑剂可能具有细胞毒性副作用。海藻酸钠/ Dextran垫的克霉唑负载纳米纤维已成功电纺。与相似的配方薄膜相比，它们表现出更多的生物粘合剂，具有更高和更快的抗真菌性能。它们在阴道中的应用需要进一步的体内研究 纳米纤维固有的柔韧性消除了对增塑剂的需求，增塑剂可能具有细胞毒性副作用。海藻酸钠/ Dextran垫的克霉唑负载纳米纤维已成功电纺。与相似的配方薄膜相比，它们表现出更多的生物粘合剂，具有更高和更快的抗真菌性能。它们在阴道中的应用需要进一步的体内研究 纳米纤维固有的柔韧性消除了对增塑剂的需求，增塑剂可能具有细胞毒性副作用。海藻酸钠/ Dextran垫的克霉唑负载纳米纤维已成功电纺。与类似的配方薄膜相比，它们表现出更多的生物粘合剂，具有更高和更快的抗真菌性能。它们在阴道中的应用需要进一步的体内研究念珠菌病。