Bacterial cellulose (BC) hydrogels are among the most efficient materials already being used for the treatment of complex wounds. The moist environment provided by the BC dressing is a key feature assuring efficient wound recovery. Improving the dressings´ moisture-holding ability facilitates its application and leads to an economically preferable extended wear time. To produce materials with reduced moisture loss, BC dressings were impregnated with a secondary hydrophilic component: alginate. The feasibility of an industrial fabrication of this composite was evaluated on pilot scale equipment. It was shown that the procedure can easily be scaled up without significantly increasing the manufacturing time. The resultant composite possessed improved water-retention properties, providing a smooth dressing exchange as demonstrated by a wound-imitating model. The new materials were moreover shown to be compatible with an antimicrobially active compound, which assures their efficiency in the treatment of highly colonized wounds.

细菌纤维素（BC）水凝胶是已经用于治疗复杂伤口的最有效材料之一。BC敷料提供的潮湿环境是确保伤口有效恢复的关键特征。改善敷料的防潮能力有利于敷料的使用，并在经济上延长了穿戴时间。为了生产减少水分流失的材料，将BC敷料浸渍了次要亲水性成分：藻酸盐。在中试规模的设备上评估了这种复合材料的工业制造可行性。结果表明，在不显着增加制造时间的情况下，可以轻松扩大该过程。所得复合材料具有改善的保水性，如伤口模拟模型所示，提供了平滑的敷料更换。此外，新材料还显示出与抗微生物活性化合物兼容，从而确保了它们在高度定植的伤口中的治疗效率。