The current work presents a novel plaster mold casting (PMC) process for fabricating functionally graded biodegradable materials (FGBMs) for orthopedics applications. According to the proposed route, the plaster molds were first prepared by using a hybrid and variable mixture of Plaster of Paris (PoP) and hydroxyapatite (HAP). Upon drying, molten magnesium (Mg) alloy was poured in the mold cavity and allowed to solidify. Various experiments have been conducted as per Taguchi based design of experimentation to study the effect of PoP_X/HAP proportion, mixing time, and baking times on mechanical, corrosion, and cytocompatibility performances of the resulting FGBM. It has been revealed by the scanning electron microscopy (SEM) that uniform layers of HAP particles were developed on the prepared specimens, revealed the novelty of the route. The mechanical properties, in case of surface hardness and impact strength, the optimum results were obtained with PoP(x = 90% by wt.) and HAP(y = 10% by wt.). Further, the corrosion investigations highlighted that the sample prepared with PoP(x = 70% by wt.) and HAP(y = 30% by wt.) proportion possessed excellent corrosion resistance. Moreover, the cytocompatibility analysis revealed that all the developed FGBM are substantially bioactive and promoted cell adhesion, proliferation, differentiation, and various other cytoplasmic activities. However, in this case, FGBM with PoP(x = 70% by wt.) and HAP(y = 30% by wt.) proportion was found superior. The overall results of the present work supported the developed FGBM components and involved the PMC route as a potential candidate for various orthopedics fabrications.

当前的工作提出了一种新颖的石膏模铸（PMC）工艺，该工艺用于制造用于骨科应用的功能梯度可生物降解材料（FGBM）。根据建议的路线，首先使用巴黎石膏（PoP）和羟基磷灰石（HAP）的混合可变混合物制备石膏模具。干燥后，将熔融的镁（Mg）合金倒入模腔中并使其固化。根据Taguchi进行的实验设计已进行了各种实验，以研究PoP _X的效果/ HAP比例，混合时间和烘烤时间对所得FGBM的机械，腐蚀和细胞相容性性能的影响。扫描电子显微镜（SEM）揭示，在制备的标本上形成了均匀的HAP颗粒层，揭示了该路线的新颖性。机械性能，在表面硬度和冲击强度的情况下，使用PoP（x = 90 wt％）和HAP（y = 10 wt％）可获得最佳结果。此外，腐蚀研究表明，以PoP（x ＝ 70重量％）和HAP（y ＝ 30重量％）的比例制备的样品具有优异的耐腐蚀性。此外，细胞相容性分析表明，所有已开发的FGBM都具有生物活性，并促进了细胞粘附，增殖，分化和其他各种细胞质活性。然而，在这种情况下，发现具有PoP（x ＝ 70重量％）和HAP（y ＝ 30重量％）比例的FGBM是更好的。本工作的总体结果支持了已开发的FGBM组件，并使PMC路线成为各种骨科制造的潜在候选者。