Hypertriglyceridemia is a risk factor for a series of diseases, such as cardiovascular disease (CVD), diabetes and nonalcoholic fatty liver disease (NAFLD). Angiopoietin-like proteins (ANGPTLs) family, especially ANGPTL3, ANGPTL4 and ANGPTL8, which regulate lipoprotein lipase (LPL) activity, play pivotal roles in triglyceride (TG) metabolism and related diseases/complications. There are many transcriptional and post-transcriptional factors that participate in physiological and pathological regulation of ANGPTLs to affect triglyceride metabolism. This review is intended to focus on the similarity and difference in the expression, structural features, regulation profile of the three ANGPTLs and inhibitory models for LPL. Description of the regulatory factors of ANGPTLs and the properties in regulating the lipid metabolism involved in the underlying mechanisms in pathological effects on diseases will provide potential therapeutic approaches for the treatment of dyslipidemia related diseases.

中文翻译：

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甘油三酸酯的代谢和血管生成素样蛋白在脂蛋白脂肪酶的调控。

高甘油三酸酯血症是一系列疾病的风险因素，例如心血管疾病（CVD），糖尿病和非酒精性脂肪肝疾病（NAFLD）。调节脂蛋白脂肪酶（LPL）活性的血管生成素样蛋白（ANGPTLs）系列，尤其是ANGPTL3，ANGPTL4和ANGPTL8，在甘油三酸酯（TG）代谢和相关疾病/并发症中起关键作用。有许多转录和转录后因子参与ANGPTL的生理和病理调节，以影响甘油三酸酯的代谢。这篇综述旨在关注三种ANGPTL的表达，结构特征，调控特性和LPL抑制模型的相似性和差异。