Magnesium (Mg) alloy shows potential application in orthopedic operations owing to its biodegradability, biocompatibility and natural bone-like mechanical properties. However, its susceptibility to corrosion in the physiological environment and bacterial infection after implantation severely limits the clinical application of Mg alloy. In order to enhance the corrosion resistance and antibacterial activity of Mg alloy to meet specific requirements of orthopedic applications, multifunctional hybrid inorganic-organic coatings were rationally designed and fabricated on the surface of Mg alloy using MgO coating, ZnO nanorods (ZnONRs), and dextran sulfate sodium/lysozyme (DS/Lys) polyelectrolyte multilayer film. It was characterized using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction (XRD). The resultant Mg-MgO-ZnONRs-(DS/Lys)₃₀ remarkably enhanced the corrosion resistance of Mg alloy by decreasing the corrosion current (i_corr) in four orders of magnitude. The biological assays showed that compared with the pristine Mg alloy, Mg-MgO-ZnONRs-(DS/Lys)₃₀ exhibited good hemocompatibility and excellent antibacterial activity (>99.9% against S. auerus and E. coli). This study provides a simple and effective way to modify the Mg alloy material as potential implant biomaterials and we anticipate this strategy will promote the broad application of Mg alloy in clinical trials.

镁（Mg）合金由于具有生物降解性，生物相容性和天然的类骨机械性能，因此在骨科手术中显示出潜在的应用前景。然而，其在植入后的生理环境和细菌感染中容易腐蚀，严重限制了镁合金的临床应用。为了增强镁合金的耐腐蚀性和抗菌活性以满足骨科应用的特定要求，在镁合金表面上合理设计和制造了多功能混合无机-有机涂层，这些涂层采用MgO涂层，ZnO纳米棒（ZnONRs）和右旋糖酐硫酸钠/溶菌酶（DS / Lys）聚电解质多层膜。使用扫描电子显微镜（SEM），X射线光电子能谱（XPS）和X射线衍射（XRD）对其进行表征。₃₀通过将腐蚀电流（i _corr）降低四个数量级，显着提高了Mg合金的耐腐蚀性。生物学分析表明，与原始的镁合金相比，Mg-MgO-ZnONRs-（DS / Lys）₃₀具有良好的血液相容性和出色的抗菌活性（抗金黄色葡萄球菌和大肠杆菌的> 99.9％）。这项研究提供了一种简单有效的方法来将镁合金材料改性为潜在的植入物生物材料，并且我们预计该策略将促进镁合金在临床试验中的广泛应用。