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The emerging PFOS alternative OBS exposure induced gut microbiota dysbiosis and hepatic metabolism disorder in adult zebrafish.
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2020-01-06 , DOI: 10.1016/j.cbpc.2020.108703 Caiyun Wang 1 , Yao Zhao 1 , Yuanxiang Jin 1
Comparative Biochemistry and Physiology C: Toxicology & Pharmacology ( IF 3.9 ) Pub Date : 2020-01-06 , DOI: 10.1016/j.cbpc.2020.108703 Caiyun Wang 1 , Yao Zhao 1 , Yuanxiang Jin 1
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Sodium ρ-perfluorous nonenoxybenzene sulfonate (OBS), as a novel the alternatives of PFASs, is widely used in many fields of life. Here, adult male zebrafish selected were exposed to OBS at concentrations of 3, 30 and 300 μg/L for 7 and 21 days, respectively. Based on the gut microbiota analysis, at genus level, the relative abundance of the Flavobacterium, Hyphomicrobium, Paracoccus, Lawsonia, Plesiomonas and Vibrio changed significantly in the gut of zebrafish after exposure to 300 μg/L OBS. In addition, the liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis suggested that a total of 1077 metabolites in pos-model and a total of 706 metabolites in neg-model changed significantly from the liver, and these changed metabolites were tightly related to several pathways including amino acid, pyrimidine and purine metabolism, etc. Furthermore, the changed gut bacteria including Flavobacterium, Hyphomicrobium, Paracoccus, Lawsonia, Plesiomonas and Vibrio at genus level were significantly correlated with various metabolites (succinic acid, leucine, xanthine, orotic acid, nicotinic acid, etc.). Taken together, all the results showed that low dose of OBS exposure could induce the dysbiosis of gut microbiota and disturbed the hepatic metabolism balance in adult male zebrafish.
中文翻译：
新兴的全氟辛烷磺酸替代OBS暴露在成年斑马鱼中引起肠道菌群失调和肝代谢异常。
ρ-全氟壬氧基苯磺酸钠（OBS）作为PFAS的新替代品，已广泛应用于生活的许多领域。在这里，选择的成年雄性斑马鱼分别在3、30和300μg/ L的OBS中暴露7天和21天。根据肠道菌群分析，在属水平下，暴露于300μg/ L的OBS后，斑马鱼的肠道中黄杆菌，次杆菌，副球菌，劳索尼亚，弯曲杆菌和弧菌的相对丰度发生了显着变化。此外，液相色谱-串联质谱（LC-MS / MS）分析表明，肝脏中pos模式中的总共1077种代谢物和neg模型中的706种代谢物从肝脏发生了显着变化，这些变化的代谢物是与多种途径密切相关，包括氨基酸，嘧啶和嘌呤代谢等。此外，在属水平上改变的肠道细菌包括黄杆菌，Hyphomicrobium，副球菌，Lawsonia，Plesiomonas和弧菌与各种代谢物（琥珀酸，亮氨酸，黄嘌呤，乳清酸，烟酸等）显着相关。综上所述，所有结果均表明，低剂量的OBS暴露可诱导成年雄性斑马鱼肠道菌群失调，并破坏肝脏的代谢平衡。
更新日期：2020-01-07
中文翻译：
新兴的全氟辛烷磺酸替代OBS暴露在成年斑马鱼中引起肠道菌群失调和肝代谢异常。
ρ-全氟壬氧基苯磺酸钠（OBS）作为PFAS的新替代品，已广泛应用于生活的许多领域。在这里，选择的成年雄性斑马鱼分别在3、30和300μg/ L的OBS中暴露7天和21天。根据肠道菌群分析，在属水平下，暴露于300μg/ L的OBS后，斑马鱼的肠道中黄杆菌，次杆菌，副球菌，劳索尼亚，弯曲杆菌和弧菌的相对丰度发生了显着变化。此外，液相色谱-串联质谱（LC-MS / MS）分析表明，肝脏中pos模式中的总共1077种代谢物和neg模型中的706种代谢物从肝脏发生了显着变化，这些变化的代谢物是与多种途径密切相关，包括氨基酸，嘧啶和嘌呤代谢等。此外，在属水平上改变的肠道细菌包括黄杆菌，Hyphomicrobium，副球菌，Lawsonia，Plesiomonas和弧菌与各种代谢物（琥珀酸，亮氨酸，黄嘌呤，乳清酸，烟酸等）显着相关。综上所述，所有结果均表明，低剂量的OBS暴露可诱导成年雄性斑马鱼肠道菌群失调，并破坏肝脏的代谢平衡。
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