This paper demonstrates the integration of a bio-functionalized tapered fiber sensor in a fiber laser cavity for sensing of biological molecules. Interferometric effect from the taper generated single wavelength lasing output that was spatially measured to detect any changes. The sensing performance of the integrated system was assessed by immersing the biosensor in various concentrations of avidin ranging from 1 to 10 pM at laser threshold (40 mW) and at the maximum pump power of 200 mW. Selectivity of the sensor was ensured by immobilizing biotin on the surface of the tapered region that would act as complementary molecules to avidin. The proposed setup obtained sensitivity values of 0.40 nm/pM and 1.02 nm/pM at pump power of 40 mW and 200 mW, respectively. The integrated system simplifies the sensing output and analysis without compromising the performance of tapered optical fiber-based biosensor.

本文演示了将生物功能化的锥形光纤传感器集成到光纤激光腔中以感应生物分子的功能。锥度产生的干涉测量效应产生了单波长激光输出，可对它进行空间测量以检测任何变化。通过将生物传感器浸入激光阈值（40 mW）和最大泵浦功率为200 mW的各种浓度的抗生物素蛋白中，其浓度范围为1至10 pM，来评估集成系统的传感性能。通过将生物素固定在锥形区域的表面上来确保传感器的选择性，该生物素将充当抗生物素蛋白的互补分子。建议的设置在40 mW和200 mW的泵浦功率下分别获得0.40 nm / pM和1.02 nm / pM的灵敏度值。