Dopamine Gates Visual Signals in Monkey Prefrontal Cortex Neurons.,Cell Reports

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Dopamine Gates Visual Signals in Monkey Prefrontal Cortex Neurons.
Cell Reports ( IF 7.5 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.celrep.2019.11.082
Maximilian Stalter ₁ , Stephanie Westendorff ₁ , Andreas Nieder ₁

Affiliation

The neurotransmitter dopamine, which acts via the D1-like receptor (D1R) and D2-like receptor (D2R) family, may play an important role in gating sensory information to the prefrontal cortex (PFC). We tested this hypothesis in awake macaques and recorded visual motion-direction tuning functions of single PFC neurons. Using micro-iontophoretic drug application combined with single-unit recordings, we simulated receptor-specific dopaminergic input to the PFC and explored cellular gating mechanisms. We find that stimulating D1Rs, and particularly D2Rs, enhances the single-neuron and population coding quality in PFC neurons. D2R stimulation causes a clear increase of the neurons' responses to the preferred motion direction and a decrease to the non-preferred motion direction, thus enhancing neuronal signal-to-noise ratio. Neither D1R nor D2R stimulation had any impact on the neurons' tuning sharpness. These results elucidate the mechanisms of how receptor-specific dopamine effects can act as a gating signal that enables privileged access of sensory information to PFC circuits.

中文翻译：

猴子前额叶皮层神经元中的多巴胺门视觉信号。

神经递质多巴胺通过D1样受体（D1R）和D2样受体（D2R）家族发挥作用，在控制前额叶皮层（PFC）的感觉信息中可能起重要作用。我们在清醒的猕猴中测试了这一假设，并记录了单个PFC神经元的视觉运动方向调节功能。使用微离子电渗疗法药物结合单单位录音，我们模拟了PFC的受体特异性多巴胺能输入，并探索了细胞门控机制。我们发现，刺激D1Rs，尤其是D2Rs，可以增强PFC神经元的单神经元和群体编码质量。D2R刺激会导致神经元对首选运动方向的响应明显增加，而对非首选运动方向的响应则减少，从而增强了神经元的信噪比。D1R和D2R刺激都不会对神经元的调谐锐度产生任何影响。这些结果阐明了受体特异性多巴胺效应如何充当门控信号的机制，该信号使感觉信息能够特权访问PFC电路。

更新日期：2020-01-07

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