Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons.,Cell Reports

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Differential Coupling of Adult-Born Granule Cells to Parvalbumin and Somatostatin Interneurons.
Cell Reports ( IF 7.5 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.celrep.2019.12.005
Ayelén I Groisman ₁ , Sung M Yang ₁ , Alejandro F Schinder ₁

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A strong GABAergic tone imposes sparse levels of activity in the dentate gyrus of the hippocampus. This balance is challenged by the addition of new granule cells (GCs) with high excitability. How developing GCs integrate within local inhibitory networks remains unknown. We used optogenetics to study synaptogenesis between new GCs and GABAergic interneurons expressing parvalbumin (PV-INs) and somatostatin (SST-INs). PV-INs target the soma, and synapses become mature after 6 weeks. This transition is accelerated by exposure to an enriched environment. PV-INs exert efficient control of GC spiking and participate in both feedforward and feedback loops, a mechanism that would favor lateral inhibition and sparse coding. SST-INs target the dendrites, and synapses mature after 8 weeks. Outputs from GCs onto PV-INs develop faster than those onto SST-INs. Our results reveal a long-lasting transition wherein adult-born neurons remain poorly coupled to inhibition, which might enhance activity-dependent plasticity of input and output synapses.

中文翻译：

成人出生的颗粒细胞与小白蛋白和生长抑素中间神经元的差分偶联。

强烈的GABA能基调使海马齿状回的活动水平降低。通过添加具有高兴奋性的新颗粒细胞（GC）来挑战这种平衡。尚待开发的GC如何整合到本地抑制网络中。我们使用光遗传学来研究新型GC与表达小白蛋白（PV-IN）和生长抑素（SST-IN）的GABA能中间神经元之间的突触形成。PV-IN靶向体细胞，突触在6周后成熟。通过暴露在丰富的环境中，可以加速这种过渡。PV-IN可有效控制GC峰，并参与前馈和反馈回路，该机制有利于横向抑制和稀疏编码。SST-INs靶向树突，并且突触在8周后成熟。从GC到PV-IN的输出要比向SST-IN的输出更快。

更新日期：2020-01-07

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