Although confirmed as the primary lipophilic antioxidant molecule endogenously produced by cells, the non-mitochondrial pool of CoQ10's functional role is still well debated. Recently, both Bersuker et al. (2019) and Doll et al. (2019) have identified FSP1 as a novel CoQ10 plasma membrane oxidoreductase, protecting cells from glutathione-independent ferroptosis.

中文翻译：

---

非线粒体 CoQ10 的抗氧化作用：谜团解开！

尽管被证实是细胞内源性产生的主要亲脂性抗氧化分子，但 CoQ10 的功能作用的非线粒体库仍然存在争议。最近，Bersuker 等人。(2019) 和 Doll 等人。(2019) 已将 FSP1 鉴定为一种新型 CoQ10 质膜氧化还原酶，可保护细胞免受不依赖谷胱甘肽的铁死亡。