Genetic and pharmacological evidence causally demonstrate that the integrated stress response (ISR) is a central molecular switch for long-term memory formation across different species. Zhu et al. (2019) recently demonstrated that persistent activation of the ISR could explain the long-term memory and synaptic plasticity deficits in a mouse model of Down syndrome, the most common genetic cause of intellectual disability.

中文翻译：

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综合压力反应：唐氏综合症中的中央记忆开关。

遗传和药理学证据有因果关系，表明综合应激反应（ISR）是跨不同物种长期记忆形成的中心分子开关。朱等。（2019）最近证明，ISR的持续激活可以解释唐氏综合症的小鼠模型的长期记忆和突触可塑性缺陷，唐氏综合症是智力障碍的最常见遗传原因。