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Therapeutic potentials of curcumin in the treatment of glioblstoma.
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.ejmech.2020.112040 Zahra Shabaninejad 1 , Mohammad Hossein Pourhanifeh 2 , Ahmad Movahedpour 3 , Reza Mottaghi 4 , Ali Nickdasti 5 , Erfan Mortezapour 5 , Alimohammad Shafiee 6 , Sarah Hajighadimi 6 , Sanaz Moradizarmehri 6 , Mohammad Sadeghian 7 , Seyed Mojtaba Mousavi 8 , Hamed Mirzaei 5
European Journal of Medicinal Chemistry ( IF 6.0 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.ejmech.2020.112040 Zahra Shabaninejad 1 , Mohammad Hossein Pourhanifeh 2 , Ahmad Movahedpour 3 , Reza Mottaghi 4 , Ali Nickdasti 5 , Erfan Mortezapour 5 , Alimohammad Shafiee 6 , Sarah Hajighadimi 6 , Sanaz Moradizarmehri 6 , Mohammad Sadeghian 7 , Seyed Mojtaba Mousavi 8 , Hamed Mirzaei 5
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Glioblastoma multiforme (GBM), a greatly aggressive malignancy of the brain, is correlated with a poor prognosis and low rate of survival. Up to now, chemotherapy and radiation therapy after surgical approaches have been the treatments increasing the survival rates. The low efficacy of mentioned therapies as well as their side-effects has forced researchers to explore an appropriate alternative or complementary treatment for glioblastoma. In experimental models, it has been shown that curcumin has therapeutic potentials to fight against GBM. Given that curcumin has pharmacological effects against cancer stem cells, as major causes of resistance to therapy in glioblastoma cells. Moreover, it has been showed that curcumin exerts its therapeutic effects on GBM cells via affecting on apoptosis, oxidant system, and inflammatory pathways. Curcumin would possess a synergistic impact with chemotherapeutic agents. Herein, we summarized the current findings on curcumin as therapeutic agent in the treatment of GBM.
中文翻译：
姜黄素治疗神经胶质瘤的治疗潜力。
多形性胶质母细胞瘤（GBM）是脑部恶性程度很高的恶性肿瘤，与预后不良和生存率低有关。迄今为止，外科手术方法之后的化学疗法和放射疗法已经成为增加存活率的疗法。提及的疗法的低效及其副作用迫使研究人员探索胶质母细胞瘤的适当替代或补充疗法。在实验模型中，已显示姜黄素具有抗GBM的治疗潜力。鉴于姜黄素具有抗癌干细胞的药理作用，这是胶质母细胞瘤细胞对治疗产生耐药性的主要原因。而且，已经显示姜黄素通过影响凋亡，氧化剂系统和炎性途径而对GBM细胞发挥其治疗作用。姜黄素将与化学治疗剂产生协同作用。本文中，我们总结了姜黄素作为治疗GBM的治疗剂的最新发现。
更新日期：2020-01-07
中文翻译：
姜黄素治疗神经胶质瘤的治疗潜力。
多形性胶质母细胞瘤（GBM）是脑部恶性程度很高的恶性肿瘤，与预后不良和生存率低有关。迄今为止，外科手术方法之后的化学疗法和放射疗法已经成为增加存活率的疗法。提及的疗法的低效及其副作用迫使研究人员探索胶质母细胞瘤的适当替代或补充疗法。在实验模型中，已显示姜黄素具有抗GBM的治疗潜力。鉴于姜黄素具有抗癌干细胞的药理作用，这是胶质母细胞瘤细胞对治疗产生耐药性的主要原因。而且，已经显示姜黄素通过影响凋亡，氧化剂系统和炎性途径而对GBM细胞发挥其治疗作用。姜黄素将与化学治疗剂产生协同作用。本文中，我们总结了姜黄素作为治疗GBM的治疗剂的最新发现。
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