Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301.,Bioorganic & Medicinal Chemistry Letters

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Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301.
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.bmcl.2019.126946
Kan'ichiro Ishiuchi ₁ , Dai Hirose ₂ , Taishi Kondo ₁ , Kohei Watanabe ₂ , Kazuyoshi Terasaka ₁ , Toshiaki Makino ₁

Affiliation

Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Ile2) and cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.

中文翻译：

Mariannamides A和B，从线虫Mariannaea elegans NBRC102301分离得到的新的环状八肽。

两种新的环状八肽，即大麻酰胺A（1）和B（2），已从Mannanaea elegans NBRC102301（一种来自松树的丝状真菌）中分离出来。阐明了它们的结构为环-（1-Leu1-1-Pro1-I-Pro2-1-Leu2-1-Ile1-I-Pro3-1-Val1-Ile2）和环-（1-Leu1-1 -Pro1-1-Pro2-I-Leu2-Ile1-I-Pro3-I-Val1-I-Val2）基于Marfey方法。Mariannamide A（1）促进C2C12细胞（一种小鼠骨骼肌成肌细胞系）中Sirtuin 1（SIRT1）的mRNA表达，并显示出对大肠杆菌和新型隐球菌的抗菌活性。

更新日期：2020-01-07

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