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Mariannamides A and B, new cyclic octapeptides isolated from Mariannaea elegans NBRC102301.
Bioorganic & Medicinal Chemistry Letters ( IF 2.5 ) Pub Date : 2020-01-07 , DOI: 10.1016/j.bmcl.2019.126946
Kan'ichiro Ishiuchi 1 , Dai Hirose 2 , Taishi Kondo 1 , Kohei Watanabe 2 , Kazuyoshi Terasaka 1 , Toshiaki Makino 1
Affiliation  

Two new cyclic octapeptides, mariannamides A (1) and B (2), have been isolated from Mariannaea elegans NBRC102301, a Pinus densiflora-derived filamentous fungus. Their structures were elucidated to be cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Ile2) and cyclo-(l-Leu1-l-Pro1-l-Pro2-l-Leu2-l-Ile1-l-Pro3-l-Val1-l-Val2) based on spectroscopic data and Marfey's method. Mariannamide A (1) promoted mRNA expression of sirtuin 1 (SIRT1) in C2C12 cells, a mouse skeletal muscle myoblast cell line, and showed the antimicrobial activity against Escherichia coli and Cryptococcus neoformans.

中文翻译:

Mariannamides A和B,从线虫Mariannaea elegans NBRC102301分离得到的新的环状八肽。

两种新的环状八肽,即大麻酰胺A(1)和B(2),已从Mannanaea elegans NBRC102301(一种来自松树的丝状真菌)中分离出来。阐明了它们的结构为环-(1-Leu1-1-Pro1-I-Pro2-1-Leu2-1-Ile1-I-Pro3-1-Val1-Ile2)和环-(1-Leu1-1 -Pro1-1-Pro2-I-Leu2-Ile1-I-Pro3-I-Val1-I-Val2)基于Marfey方法。Mariannamide A(1)促进C2C12细胞(一种小鼠​​骨骼肌成肌细胞系)中Sirtuin 1(SIRT1)的mRNA表达,并显示出对大肠杆菌和新型隐球菌的抗菌活性。
更新日期:2020-01-07
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