BACKGROUND Experimental evidence has revealed that exposure to polychlorinated biphenyls (PCBs) and dioxins directly impairs endothelial function and induces atherosclerosis progression. In the general population, despite a small number of recent studies finding a link between PCBs, and stroke and myocardial infraction, the association with early coronary atherosclerosis has not been examined yet. OBJECTIVE To examine whether dietary exposure to PCBs and dioxins is associated with subclinical coronary atherosclerosis in a middle-aged men. DESIGN Cross-sectional analysis comprising 1844 men in their 50 s and free of cardiovascular disease, who participated in the Aragon Workers' Health Study (AWHS). Individual dietary exposures to PCBs and dioxins were estimated by the contaminant's concentration in food coupled with the corresponding consumption and then participants were classified into quartiles of consumption. Coronary artery calcium score (CACS) was assessed by computerized tomography. We conducted ordered logistic regressions to estimate the odds ratio (OR) and 95% confidence intervals (CIs) for progression to the categories of more coronary artery calcium, adjusting for potential confounders. RESULTS Among the participants, coronary calcium was not shown in 60.1% (n = 1108), 29.8% had a CACS > 0 and <100 (n = 550), and the remaining 10.1% (n = 186) had a CACS ≥ 100. Compared with those in the first quartile of PCBs exposure, those in the fourth one had an increased odds for having coronary calcium (OR 2.02, 95% CI [1.18, 3.47], p trend 0.019) and for having progressed to categories of more intense calcification (OR 2.03, 95% CI [1.21, 3.40], p trend 0.012). However, no association was found between dietary dioxins exposure and prevalent coronary artery calcium. CONCLUSIONS In this general male population, dietary exposure to PCBs, but not to dioxins, was associated with a higher prevalence of coronary calcium and to more intense subclinical coronary atherosclerosis. PCBs exposure seems to increase the risk of coronary disease in men from the very early stages.

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饮食中多氯联苯和二恶英的暴露及其与亚临床冠状动脉粥样硬化的关系：《阿拉贡工人健康研究》。

背景技术实验证据表明，暴露于多氯联苯（PCBs）和二恶英会直接损害内皮功能并诱导动脉粥样硬化进展。在一般人群中，尽管最近进行的少量研究发现PCB与卒中和心肌梗塞之间存在联系，但尚未检查与早期冠状动脉粥样硬化的关系。目的探讨饮食摄入多氯联苯和二恶英是否与中年男性亚临床冠状动脉粥样硬化有关。设计横断面分析包括1844名50年代无心血管疾病的男性，他们参加了阿拉贡工人健康研究（AWHS）。膳食中多氯联苯和二恶英的暴露量是根据污染物的“ 的食物浓度和相应的消费量，然后将参与者分为消费量的四分位数。通过计算机断层扫描评估冠状动脉钙化评分（CACS）。我们进行了有序的逻辑回归，以评估发展到更多冠状动脉钙的类别的可能性比（OR）和95％置信区间（CIs），并调整了潜在的混杂因素。结果在参与者中，未显示冠状动脉钙的比例为60.1％（n = 1108），29.8％的CACS> 0和<100（n = 550），其余的10.1％（n = 186）的CACS≥100与PCBs暴露的第一个四分位数相比，第四个四分位数的人罹患冠状动脉钙的机率增加（OR 2.02，95％CI [1.18，3.47]，p趋势为0。019），并且已经发展为钙化程度更高的类别（OR 2.03，95％CI [1.21、3.40]，p趋势0.012）。但是，在饮食中摄入二恶英与普遍的冠状动脉钙化之间没有关联。结论在这个普通男性人群中，饮食中多氯联苯的摄入，而不是二恶英的摄入，与冠状动脉钙的患病率更高和亚临床冠状动脉粥样硬化程度有关。从早期开始，PCBs的暴露似乎会增加男性患冠心病的风险。与冠状动脉钙化患病率更高和亚临床冠状动脉粥样硬化程度更高有关。从早期开始，PCBs的暴露似乎会增加男性患冠心病的风险。与冠状动脉钙化患病率更高和亚临床冠状动脉粥样硬化程度更高有关。从早期开始，PCBs的暴露似乎会增加男性患冠心病的风险。