Understanding the mechanisms behind neurodifferentiation in adults will be an important milestone in our quest to identify treatment strategies for cognitive disorders observed during our natural ageing or disease. It is now clear that the maturation of neural stem cells to neurones, fully integrated into neuronal circuits requires a complete remodelling of cellular metabolism, including switching the cellular energy source. Mitochondria are central for this transition and are increasingly seen as the regulatory hub in defining neural stem cell fate and neurodevelopment. This review explores our current knowledge of metabolism during adult neurodifferentiation.

中文翻译：

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成人大脑神经分化的代谢调节。

了解成人神经分化背后的机制将是我们寻求自然衰老或疾病期间观察到的认知障碍的治疗策略的一个重要里程碑。现在很清楚，神经干细胞成熟为神经元并完全融入神经元回路需要彻底重塑细胞代谢，包括切换细胞能量来源。线粒体是这一转变的核心，并且越来越多地被视为定义神经干细胞命运和神经发育的调节中心。这篇综述探讨了我们目前对成人神经分化过程中新陈代谢的了解。