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Electrochemical biosensors based on nucleic acid aptamers.
Analytical and Bioanalytical Chemistry ( IF 3.8 ) Pub Date : 2020-01-07 , DOI: 10.1007/s00216-019-02226-x
Anabel Villalonga 1 , Ana María Pérez-Calabuig 1 , Reynaldo Villalonga 1
Affiliation  

During recent decades, nucleic acid aptamers have emerged as powerful biological recognition elements for electrochemical affinity biosensors. These bioreceptors emulate or improve on antibody-based biosensors because of their excellent characteristics as bioreceptors, including limitless selection capacity for a large variety of analytes, easy and cost-effective production, high stability and reproducibility, simple chemical modification, stable and oriented immobilization on electrode surfaces, enhanced target affinity and selectivity, and possibility to design them in target-sensitive 3D folded structures. This review provides an overview of the state of the art of electrochemical aptasensor technology, focusing on novel aptamer-based electroanalytical assay configurations and providing examples to illustrate the different possibilities. Future prospects for this technology are also discussed. Graphical abstract.

中文翻译:

基于核酸适体的电化学生物传感器。

在最近的几十年中,核酸适体已经成为电化学亲和力生物传感器的强大的生物识别元件。这些生物受体在基于抗体的生物传感器上可以模仿或改进,因为它们具有出色的生物受体特性,包括对多种分析物的无限选择能力,简便且经济高效的生产,高稳定性和可重复性,简单的化学修饰,稳定且定向的固定电极表面,增强的目标亲和力和选择性,以及在目标敏感的3D折叠结构中进行设计的可能性。这篇综述概述了电化学适体传感器技术的发展水平,重点介绍了基于新型适体的电分析检测配置,并提供了示例来说明不同的可能性。还讨论了该技术的未来前景。图形概要。
更新日期:2020-01-07
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