Intramolecular hydride transfer has long been recognized as a powerful method to generate new stereogenic centers induced by the existing stereogenic center(s). Synthetically significant selectivities are usually obtained through 1,5‐hydride transfer within six‐membered ring. This mini‐review focuses on a transannular hydride transfer generating up to three stereocenters simultaneously from a single stereogenic center through formation of medium rings, mostly eight‐membered rings, in mild reaction conditions. The corresponding linear products with multiple stereocenters are potentially useful building blocks for synthesis of complex molecules including polyketide natural products.

中文翻译：

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通过中等周期形成/分子内氢化物转移级联进行远程手性转移

长期以来，分子内氢化物转移被认为是产生由现有立体异构中心诱导的新立体异构中心的有效方法。通常，通过在六元环内进行1,5-氢化物转移，可以获得合成上显着的选择性。这篇小型综述的重点是在温和的反应条件下，通过一个中性环（主要是八元环）的形成，从一个立体生成中心同时生成多达三个立体中心的跨环氢化物转移。具有多个立体中心的相应线性产物是合成包括聚酮化合物天然产物的复杂分子的潜在有用的构建基块。