In this study, an obese mouse model was developed by administering a high sugar and fat diet for 60 days, followed by administration of a special dietary supplement of Ganoderma lucidum extract for another 35 days. Then, the changes in histopathology of the liver, adipose, colon, intestines, spleen, renal and brain tissues; metabolism and transcription; and gut microbiota were monitored. The results showed that alcohol extracts of the G. lucidum fruit body could reduce body weight; change the serum levels of lipid; ameliorate the damage to the gut microbiota, colon, liver, brain and other organs induced by the high sugar and fat diet; and activate the leptin regulatory pathways in the hypothalamus to improve metabolism. These findings indicate that administration of the alcohol extracts of the G. lucidum fruit body has beneficial effects on the microbiome-gut-liver and microbiome-gut-brain axes, and activates leptin-mediated signaling to improve metabolic regulation.

在这项研究中，通过给予高糖和高脂肪饮食60天，然后再给予特殊的膳食补充灵芝提取物持续35天来开发肥胖小鼠模型。然后，肝脏，脂肪，结肠，肠，脾，肾和脑组织的病理组织学改变；代谢和转录；监测肠道菌群。结果表明灵芝的醇提取物子实体可以减轻体重；改变血脂的血清水平；改善高糖和高脂饮食对肠道菌群，结肠，肝脏，大脑和其他器官的损害；并激活下丘脑中的瘦素调节途径，以改善新陈代谢。这些发现表明，灵芝子实体的醇提取物的施用对微生物-肠-肝和微生物-肠-脑轴具有有益的作用，并激活瘦蛋白介导的信号传导以改善代谢调节。