Pharmaceutical and Personal Care Products (PPCPs) removal coupling with bioenergy production by microalgae has attracted growing attention. However, the biological interactions between PPCPs and microalgae are unclear during microalgal biosorption and biodegradation of PPCPs. In this study, an optimal ciprofloxacin (CIP) and sulfadiazine (SDZ) removal efficiency were achieved 100% and 54.53% with carbohydrate productivity of >1000 mg L⁻¹ d⁻¹ by Chlamydomonas sp. Tai-03, respectively. The elimination routes indicated that CIP removal was mainly achieved by biodegradation (65.05%) whereas SDZ was mainly removed by photolysis (35.60%). The visualization evidence of microscopic imaging Raman spectrometer supported the favorable biosorption of CIP due to its positive charge (+10.20 mV). Meanwhile, the tendency for gradual reduction of CIP in extracellular polymeric substances (EPS) indicated that suspended microalgal cell facilitated CIP uptake and biodegradation. Furthermore, photolysis and biodegradation pathways were thoroughly analyzed to demonstrate that intermediates were less toxic and had no adverse effect on the subsequent ethanol conversion. This study provides valuable information for the development of a novel microalgal PPCPs removal. These findings reveal the possible biological mechanisms of biosorption and biodegradation of PPCPs in microalgae, which could further enhance the feasibility of microalgal applications for simultaneous PPCPs remediation and alternative energy production.

去除药物和个人护理产品（PPCP）以及通过微藻产生生物能已引起越来越多的关注。然而，在PPCP的微藻生物吸附和生物降解过程中，PPCP与微藻之间的生物学相互作用尚不清楚。在这项研究中，最佳的环丙沙星（CIP）和磺胺嘧啶（SDZ）去除率分别实现100％，并且具有> 1000毫克的L的碳水化合物生产率54.53％^-1 d ^-1由衣sp。大三分别。消除途径表明，CIP去除主要通过生物降解实现（65.05％），而SDZ主要通过光解去除（35.60％）。显微成像拉曼光谱仪的可视化证据表明CIP具有正电荷（+10.20 mV），支持了良好的生物吸附。同时，细胞外聚合物（EPS）中CIP逐渐降低的趋势表明，悬浮的微藻细胞促进了CIP的吸收和生物降解。此外，对光解和生物降解途径进行了彻底分析，以证明中间体毒性较低，并且对随后的乙醇转化没有不利影响。这项研究为开发新型微藻类PPCP去除提供了有价值的信息。