Organic phosphorescence materials with longlived triplet excitons that can highly generate active singlet oxygen (¹O₂) through the energy transfer with the molecular oxygen under photoexcitation, serve as highly efficient antibacterial agent. Herein, we report bright red-emissive organic phosphorescent nanoparticles (PNPs) based on a metal-free organic phosphor encapsulated with biocompatible block copolymers. The obtained PNPs with an ultra-small particle size of around 5 nm and a long emission lifetime of up to 167 µs showed effective 1O2 generation ability under visible light (410 nm) excitation in aqueous media, which can efficiently eradicate multi-drug resistant bacteria both in vitro and in vivo. This is the first demonstration of metal-free organic PNPs for photodynamic antimicrobial therapy, expanding the application scope of metal-free organic room temperature phosphorescent materials.

具有长寿命三重态激子的有机磷光材料可在光激发下通过与分子氧的能量转移而高度生成活性单线态氧（¹ O ₂），是高效的抗菌剂。在本文中，我们报告了基于生物相容性嵌段共聚物封装的无金属有机磷光体的亮红色发射有机磷光纳米颗粒（PNP）。所获得的PNP具有5nm左右的超小粒径和高达167µs的长发射寿命，在可见光（410 nm）激发下在水性介质中显示出有效的1O2生成能力，可以有效消灭耐多药细菌二者在体外和体内。这是用于光动力抗菌疗法的无金属有机PNP的首次展示，扩大了无金属有机室温磷光材料的应用范围。