Killing Oral Bacteria Using Metal–Organic Frameworks,Industrial & Engineering Chemistry Research

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Killing Oral Bacteria Using Metal–Organic Frameworks
Industrial & Engineering Chemistry Research ( IF 3.8 ) Pub Date : 2020-01-14 , DOI: 10.1021/acs.iecr.9b05659
Piao Cao ₁ , Xiaojun Wu ₂ , Wenbo Zhang ₁ , Ling Zhao _{1,

3} , Weizhen Sun ₁ , Zisheng Tang _{4,

5,

6}

Affiliation

Metal–organic frameworks (MOFs), with enormous internal surface areas, ultrahigh porosity, and designable structure consisting of organic and inorganic components, have the potential application value that has not been fully explored in biological sterilization. In this work, the sustained-release sterilization abilities of three different MOFs, that is, [AgL]_n·nH₂O (p-MOF), MOF-5, and ZIF-8, against three typical oral bacteria were studied using sustained-release curve measurement, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide reduction assay, and growth curve determination. Compared with traditional antibacterial materials, such as silver nitrate (AgNO₃), the p-MOF material exhibits better slow-release bactericidal properties. The sterilization property of MOFs containing Ag⁺ ions is better than that of MOFs containing Zn²⁺ ions. In addition, the sterilization time of MOFs in the solid phase is longer than that of MOFs in the liquid phase, which is ascribed to the slow release rate of metal ions in the frameworks of solid-phase MOFs. Moreover, the sustained-release property of MOFs is strongly associated with their structural characteristics and the corresponding chemical stability. Hopefully, this work can bring new insights into a new competitive antibacterial material against oral bacteria and the rational design of antibacterial MOFs.

中文翻译：

使用金属有机框架杀死口腔细菌

金属有机骨架（MOF）具有巨大的内表面积，超高孔隙率以及由有机和无机成分组成的可设计结构，具有潜在的应用价值，这在生物灭菌中尚未得到充分探索。在这项工作中，研究了三种不同的MOF，即[AgL] _n · n H ₂ O（p-MOF），MOF-5和ZIF-8对三种典型口腔细菌的缓释杀菌能力，方法如下：缓释曲线测定，3-（4,5-二甲基噻唑-2-基）-2,5-二苯基溴化四唑还原测定法和生长曲线测定。与传统的抗菌材料相比，例如硝酸银（AgNO ₃），p-MOF材料表现出更好的缓释杀菌性能。含Ag ⁺离子的MOF的杀菌性能优于含Zn ²⁺离子的MOF的杀菌性能。另外，固相MOF的杀菌时间比液相MOF的杀菌时间长，这归因于固相MOF骨架中金属离子的缓慢释放速率。此外，MOF的持续释放特性与其结构特征和相应的化学稳定性密切相关。希望这项工作可以为针对口腔细菌的新型竞争性抗菌材料和抗菌MOF的合理设计带来新的见解。

更新日期：2020-01-15

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