Instructive Advances in Chemical Microbiology Inspired by Nature's Diverse Inventory of Molecules.,ACS Infectious Diseases

当前位置： X-MOL 学术 › ACS Infect. Dis. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Instructive Advances in Chemical Microbiology Inspired by Nature's Diverse Inventory of Molecules.
ACS Infectious Diseases ( IF 4.0 ) Pub Date : 2020-01-06 , DOI: 10.1021/acsinfecdis.9b00413
Ke Liu ₁ , Robert W Huigens ₁

Affiliation

Natural product antibiotics have played an essential role in the treatment of bacterial infection in addition to serving as useful tools to explore the intricate biology of bacteria. Our current arsenal of antibiotics operate through the inhibition of well-defined bacterial targets critical for replication and growth. Pathogenic bacteria effectively utilize a diversity of mechanisms that lead to acquired resistance and/or innate tolerance toward antibiotic therapies, which can result in devastating consequences to human life. Several research groups have established innovative programs that work at the chemistry-biology interface to develop new molecules that aim to define and address concerns related to antibiotic resistance and tolerance. In this Review, we present recent progress by select research groups that highlight a diversity of integrated chemical biology and medicinal chemistry approaches aimed at the development and utilization of chemical tools that have led to promising new microbiological insights that may lead to significant clinical advances regarding the treatment of pathogenic bacteria.

中文翻译：

受自然界多样化分子库存的启发，化学微生物学取得了有益的进展。

天然产物抗生素除了作为探索细菌复杂生物学的有用工具外，在细菌感染的治疗中发挥着重要作用。我们目前的抗生素库通过抑制对复制和生长至关重要的明确细菌靶标来发挥作用。致病细菌有效地利用多种机制，导致对抗生素治疗产生获得性耐药性和/或先天耐受性，这可能对人类生命造成毁灭性后果。几个研究小组已经建立了在化学-生物学界面上工作的创新计划，以开发新分子，旨在定义和解决与抗生素耐药性和耐受性相关的问题。在这篇综述中，我们介绍了精选研究小组的最新进展，这些进展强调了旨在开发和利用化学工具的综合化学生物学和药物化学方法的多样性，这些方法带来了有希望的新的微生物学见解，可能会带来关于化学工具的重大临床进展。治疗致病菌。

更新日期：2019-12-16

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11