Computer simulations had predicted that amyloid fibrillogenesis is governed by free energy barriers and kinetic traps (kinetic control), rather than the free energy of the final aggregates. The simulations suggested that the diversity in fibril morphologies can originate from variations in the number of protofilaments which has been confirmed by recent cryo-electron microscopy studies of amyloid-β fibrils derived from brain tissue of Alzheimer's patients. The kinetic control of fibril formation and polymorphism imply that chemical substances with new mechanisms of action are needed to fight Alzheimer's disease.

中文翻译：

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淀粉样蛋白生成的动力学控制需要非常规药物来对抗阿尔茨海默氏病。

计算机模拟已经预测淀粉样蛋白原纤维形成是由自由能垒和动力学陷阱（动力学控制）而不是最终聚集体的自由能支配的。该模拟表明原纤维形态的多样性可以源自原丝数目的变化，这已经由最近的对来自阿尔茨海默氏病患者的脑组织的β-淀粉样蛋白原纤维的低温电子显微镜研究证实。对原纤维形成和多态性的动力学控制意味着需要具有新作用机理的化学物质来对抗阿尔茨海默氏病。