DARK Classics in Chemical Neuroscience: Kava.,ACS Chemical Neuroscience

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DARK Classics in Chemical Neuroscience: Kava.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-01-06 , DOI: 10.1021/acschemneuro.9b00587
Andrey Volgin _{1,

2} , LongEn Yang ₁ , Tamara Amstislavskaya ₂ , Konstantin Demin _{3,

4} , Dongmei Wang ₁ , Dongni Yan ₁ , Jingtao Wang ₁ , Mengyao Wang ₁ , Erik Alpyshov ₁ , Guojun Hu ₁ , Nazar Serikuly _{1,

5} , Vadim Shevyrin ₆ , Edina Wappler-Guzzetta ₇ , Murilo de Abreu ₈ , Allan Kalueff _{1,

4,

6,

9}

Affiliation

Kava (kava kava, Piper methysticum) is a common drug-containing plant in the Pacific islands. Kavalactones, its psychoactive compounds, exert potent central nervous system (CNS) action clinically and in animal models. However, the exact pharmacological profiles and mechanisms of action of kava on the brain and behavior remain poorly understood. Here, we discuss clinical and experimental data on kava psychopharmacology and summarize chemistry and synthesis of kavalactones. We also review its societal impact, drug use and abuse potential, and future perspectives on translational kava research.

中文翻译：

化学神经科学的黑暗经典：卡瓦。

卡瓦酒（kava kava、 Piper methysticum ）是太平洋岛屿常见的含药植物。卡瓦内酯是其精神活性化合物，在临床和动物模型中发挥有效的中枢神经系统（CNS）作用。然而，卡瓦酒对大脑和行为的确切药理学特征和作用机制仍然知之甚少。在这里，我们讨论卡瓦精神药理学的临床和实验数据，并总结卡瓦内酯的化学和合成。我们还回顾了其社会影响、药物使用和滥用潜力以及转化卡瓦研究的未来前景。

更新日期：2020-01-06

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