Over the last years, orthopedic procedures for bone repairs have been developed due to an increase in trauma and diseases. The development of bioactive composites using biodegradable polymers like poly(lactic acid) (PLA) and bioactive fillers as hydroxyapatite (HA) originate biomaterials, which combine bioactivity of HA and PLA biocompatibility. Therefore, using additive manufacturing is possible for the production of customized products made from these materials; however, a thorough study of these materials is required. In this context, melt‐compounding has been used to manufacture bioactive composites of PLA/HA, and rheological, molecular, and thermomechanical behavior were assessed. The biocomposite of PLA with 10 wt% HA presented a strong shear thinning behavior, which makes it more suitable for fused filament fabrication since lower printing pressure is required. Furthermore, this composite presented an enhancement of 12% in thermomechanical properties in comparison to PLA and a slight increase in cell proliferation. PLA and PLA/HA were fabricated and used to produce 3D calibrations cube as a proof of concept. They presented good printability and high accuracy, and therefore, further investigation needs to be performed to unleash its use in bone tissue engineering applications. POLYM. ENG. SCI., 60:636–644, 2020. © 2020 Society of Plastics Engineers

中文翻译：

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聚乳酸/羟基磷灰石生物相容性复合材料的制备及其在医学上的应用

近年来，由于创伤和疾病的增加，已经开发了用于骨修复的骨科程序。使用可生物降解的聚合物（如聚乳酸（PLA）和生物活性填料作为羟基磷灰石（HA））开发生物活性复合材料是一种结合了HA和PLA生物相容性的生物材料。因此，可以使用增材制造来生产由这些材料制成的定制产品。但是，需要对这些材料进行彻底的研究。在这种情况下，熔融混合已被用于制造PLA / HA的生物活性复合材料，并评估了流变，分子和热机械行为。具有10 wt％HA的PLA生物复合材料具有很强的剪切稀化行为，由于需要较低的印刷压力，因此它更适合于熔丝的制造。此外，与PLA相比，该复合材料的热机械性能提高了12％，细胞增殖略有增加。制造PLA和PLA / HA并将其用于生产3D校准立方体作为概念证明。它们具有良好的可印刷性和高精度，因此，需要进行进一步的研究以释放其在骨组织工程应用中的用途。POLYM。ENG。SCI。，60：636–644，2020.©2020塑料工程师协会 制造PLA和PLA / HA并将其用于生产3D校准立方体作为概念证明。它们具有良好的可印刷性和高精度，因此，需要进行进一步的研究以释放其在骨组织工程应用中的用途。POLYM。ENG。SCI。，60：636–644，2020.©2020塑料工程师协会 制造PLA和PLA / HA并将其用于生产3D校准立方体作为概念证明。它们具有良好的可印刷性和高精度，因此，需要进行进一步的研究以释放其在骨组织工程应用中的用途。POLYM。ENG。SCI。，60：636–644，2020.©2020塑料工程师协会