The checkpoint kinase 1 (CHK1) is a master regulator of genome integrity in vertebrate cells. Despite its important cell cycle functions, its regulation is still incompletely understood. Cassidy et al. provide novel insights on the regulation of the CHK1 abundance by the HECT E3 ligase HUWE1 during unperturbed cell cycle as well as in response to replicative stress. These results may help us to apprehend the underlying mechanism of tumorigenesis.

中文翻译：

---

泛素-蛋白酶体系统对CHK1的调节。

检查点激酶1（CHK1）是脊椎动物细胞中基因组完整性的主要调节剂。尽管其重要的细胞周期功能，其调节仍不完全了解。卡西迪等。在不受干扰的细胞周期以及对复制应激的反应中，提供了有关HECT E3连接酶HUWE1对CHK1丰度的调控的新颖见解。这些结果可能有助于我们理解肿瘤发生的潜在机制。