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Structures of virus-like capsids formed by the Drosophila neuronal Arc proteins
Nature Neuroscience ( IF 21.2 ) Pub Date : 2020-01-06 , DOI: 10.1038/s41593-019-0569-y Simon Erlendsson 1 , Dustin R Morado 1 , Harrison B Cullen 2 , Cedric Feschotte 2 , Jason D Shepherd 3 , John A G Briggs 1
中文翻译：
果蝇神经元弧蛋白形成的病毒样衣壳结构
更新日期：2020-01-06
Nature Neuroscience ( IF 21.2 ) Pub Date : 2020-01-06 , DOI: 10.1038/s41593-019-0569-y Simon Erlendsson 1 , Dustin R Morado 1 , Harrison B Cullen 2 , Cedric Feschotte 2 , Jason D Shepherd 3 , John A G Briggs 1
Affiliation
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Arc, a neuronal gene that is critical for synaptic plasticity, originated through the domestication of retrotransposon Gag genes and mediates intercellular messenger RNA transfer. We report high-resolution structures of retrovirus-like capsids formed by Drosophila dArc1 and dArc2 that have surface spikes and putative internal RNA-binding domains. These data demonstrate that virus-like capsid-forming properties of Arc are evolutionarily conserved and provide a structural basis for understanding their function in intercellular communication.
中文翻译：
果蝇神经元弧蛋白形成的病毒样衣壳结构
Arc是一种对突触可塑性至关重要的神经元基因，起源于逆转录转座子Gag基因的驯化，并介导细胞间信使 RNA 转移。我们报告了由果蝇dArc1 和 dArc2形成的逆转录病毒样衣壳的高分辨率结构，这些衣壳具有表面尖峰和假定的内部 RNA 结合域。这些数据表明 Arc 的病毒样衣壳形成特性在进化上是保守的，并为理解它们在细胞间通讯中的功能提供了结构基础。
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