Effect of fluctuation of oxygenation on the development of severe retinopathy of prematurity in extremely preterm infants.,Journal of Perinatology

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Effect of fluctuation of oxygenation on the development of severe retinopathy of prematurity in extremely preterm infants.
Journal of Perinatology ( IF 2.4 ) Pub Date : 2020-01-06 , DOI: 10.1038/s41372-019-0571-y
Yousuke Imanishi ₁ , Katsuya Hirata ₁ , Masatoshi Nozaki ₁ , Narutaka Mochizuki ₁ , Shinya Hirano ₁ , Yoko Fukushima ₂ , Yoshikazu Hatsukawa ₂ , Kazuko Wada ₁

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OBJECTIVE To investigate factors associated with development of severe retinopathy of prematurity (ROP) in extremely preterm (EP) infants. STUDY DESIGN This retrospective cohort study included 213 EP infants (22 + 0 to 27 + 6 weeks gestation) who were admitted to the neonatal intensive care unit of Osaka Women's and Children's Hospital between 2009 and 2017. Multivariable logistic regression analysis was used to identify neonatal factors associated with severe ROP requiring treatment. RESULT After adjustments for gestational age (GA), birth weight, sex, red blood cell transfusion, average SpO2, and fluctuations of SpO2 from birth to 32 weeks postmenstrual age, fluctuations of SpO2 (odds ratio [OR]: 2.10, 95% confidence interval [CI]: 1.03-4.27), and low GA (OR: 0.95, 95% CI: 0.91-0.98) were significantly associated with severe ROP. CONCLUSIONS Fluctuations of SpO2 from birth to 32 weeks postmenstrual age and low GA were significantly associated with development of severe ROP requiring treatment in EP infants.

中文翻译：

氧合波动对极端早产儿严重早产儿视网膜病变的影响。

目的探讨与极早产儿严重早产儿视网膜病变（ROP）发展有关的因素。研究设计这项回顾性队列研究纳入了2009年至2017年间大阪妇女儿童医院新生儿重症监护室收治的213名EP婴儿（22 + 0至27 + 6周妊娠）。多因素逻辑回归分析用于识别新生儿与严重ROP相关的因素需要治疗。结果在调整了胎龄（GA），出生体重，性别，红细胞输注，平均SpO2以及从出生到月经后32周的SpO2波动后，SpO2波动（赔率[OR]：2.10，95％置信度）间隔[CI]：1.03-4.27）和低GA（OR：0.95，95％CI：0.91-0.98）与严重的ROP显着相关。

更新日期：2020-01-06

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