Sandwich-Like Sensor for the Highly Specific and Reproducible Detection of Rhodamine 6G on a Surface-Enhanced Raman Scattering Platform.,ACS Applied Materials & Interfaces

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Sandwich-Like Sensor for the Highly Specific and Reproducible Detection of Rhodamine 6G on a Surface-Enhanced Raman Scattering Platform.
ACS Applied Materials & Interfaces ( IF 8.3 ) Pub Date : 2020-01-15 , DOI: 10.1021/acsami.9b16773
Jing Wang ₁ , Jingyi Li ₁ , Chuan Zeng ₂ , Qi Qu ₁ , Mengfan Wang _{1,

3} , Wei Qi _{1,

3,

4} , Rongxin Su _{1,

3,

4} , Zhimin He ₁

Affiliation

Nonspecificity and low reproducibility are always the main challenges in surface-enhanced Raman scattering (SERS) detection, especially for testing real samples. In this study, we developed a sandwich-like sensor (AuA-pMIP) to detect rhodamine 6G (R6G) by integrating a porous molecularly imprinted polymer (pMIP) with a well-ordered AuNP array (AuA). To form a uniformly distributed hot spot, AuA was fabricated at an oil-water interface and was subsequently fixed between pMIP and a support slide. Finite-difference time-domain simulation indicated that the enhanced electric field covered a distance of ∼2 μm above the AuA, in which the pMIP provided effective mass-transfer channels and sufficient specific binding sites for target molecules. High specificity for AuA-pMIP in R6G detection was demonstrated by comparing the SERS performance of R6G on AuA-pMIP with that of its structural analogues on the same sensor. Remarkably, the stable sandwich-like structure allowed us to achieve a recyclable SERS sensor with high reproducibility. Finally, AuA-pMIP displayed excellent specificity and sensitivity toward R6G in a test based on a real orange juice sample. This study presents a promising method to achieve real sample testing on a SERS platform.

中文翻译：

类似于三明治的传感器，用于在表面增强拉曼散射平台上高特异性和可重复性检测罗丹明6G。

非特异性和低重现性始终是表面增强拉曼散射（SERS）检测的主要挑战，特别是对于测试真实样品。在这项研究中，我们开发了一种类似三明治的传感器（AuA-pMIP），通过将多孔分子印迹聚合物（pMIP）与井井有条的AuNP阵列（AuA）集成在一起来检测罗丹明6G（R6G）。为了形成均匀分布的热点，在油-水界面处制造了AuA，然后将其固定在pMIP和支撑玻片之间。时域有限差分模拟表明，增强的电场覆盖了距AuA约2μm的距离，其中pMIP为目标分子提供了有效的传质通道和足够的特异性结合位点。通过比较R6G在AuA-pMIP上的SERS性能与其在相同传感器上的结构类似物的SERS性能，证明了R6G检测中AuA-pMIP的高特异性。值得注意的是，稳定的三明治状结构使我们能够实现具有高重现性的可回收SERS传感器。最后，在基于真实橙汁样品的测试中，AuA-pMIP对R6G表现出出色的特异性和敏感性。这项研究提出了一种有前途的方法，可以在SERS平台上实现真实的样品测试。

更新日期：2020-01-16

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