A self-assembled peptide hydrogel for cytokine sequestration.,Journal of Materials Chemistry B

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A self-assembled peptide hydrogel for cytokine sequestration.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-01-10 , DOI: 10.1039/c9tb02250c
Ka-Kyung Kim ₁ , Zain Siddiqui ₁ , Manali Patel ₁ , Biplab Sarkar ₁ , Vivek A Kumar ₂

Affiliation

Cytokine-directed monocyte infiltration is involved in multiple pathological processes. Immuno-isolating matrices that can sequester cell-released chemokines in a microenvironment may prolong the viability and functionality of implanted materials. We describe a self-assembling peptide-based hydrogel that can capture the cytokine CCL2 released in the extracellular space by immune cells and stromal cells. The shear-responsive matrix can absorb and retain this signaling molecule needed for the chemotaxis of the infiltrating monocytes and their differentiation into phagocytic macrophages. Such cytokine-sequestering biomaterials may be useful as adjunctive materials with the delivery of exogenous implants or cell suspensions for tissue regeneration, without the administration of systemic immunosuppressants. Our work highlights the versatility of nanofibrous peptide hydrogels for modulating the biological response in tissue niches.

中文翻译：

一种用于细胞因子隔离的自组装肽水凝胶。

细胞因子定向的单核细胞浸润参与多种病理过程。可以在微环境中隔离细胞释放的趋化因子的免疫隔离基质可以延长植入材料的活力和功能。我们描述了一种自组装肽基水凝胶，它可以捕获免疫细胞和基质细胞在细胞外空间释放的细胞因子 CCL2。剪切反应基质可以吸收并保留浸润单核细胞趋化性和分化为吞噬性巨噬细胞所需的信号分子。这种细胞因子螯合生物材料可用作辅助材料，用于递送外源性植入物或用于组织再生的细胞悬浮液，而无需施用全身免疫抑制剂。

更新日期：2020-02-13

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