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Fabrication of 3D plotted scaffold with microporous strands for bone tissue engineering.
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-01-10 , DOI: 10.1039/c9tb02360g Ji Min Seok 1 , Thanavel Rajangam 2 , Jae Eun Jeong 3 , Sinyoung Cheong 4 , Sang Min Joo 4 , Seung Ja Oh 2 , Heungsoo Shin 5 , Sang-Heon Kim 6 , Su A Park 3
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-01-10 , DOI: 10.1039/c9tb02360g Ji Min Seok 1 , Thanavel Rajangam 2 , Jae Eun Jeong 3 , Sinyoung Cheong 4 , Sang Min Joo 4 , Seung Ja Oh 2 , Heungsoo Shin 5 , Sang-Heon Kim 6 , Su A Park 3
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Scaffold porosity has played a key role in bone tissue engineering aimed at effective tissue regeneration, by promoting cell attachment, proliferation, and osteogenic differentiation for new bone formation. Three-dimensional plotting systems (3DPSs) have been widely used to introduce porosity to the scaffold; however, introducing certain features in the scaffold strands that improve bone tissue regeneration remains a challenge. In this work, we fabricated bone tissue scaffolds with macro- and microporous structural features using a 3DPS and non-solvent-induced phase separation method. This approach allowed both macro- and micropores to be created in the scaffold strands. The surface morphology and mechanical and degradation properties of the perforated scaffolds were characterized carefully. Human marrow stromal cells were cultured on the scaffolds and then analyzed in vitro to assess scaffold bio-function. The highly porous scaffold exhibited mechanical properties similar to those of cancellous bone. Cell attachment, proliferation, and differentiation were significantly higher in porous scaffold compared to its nonporous counterpart. These results suggest that highly porous scaffolds have tremendous potential as a bone tissue regeneration platform.
中文翻译：
3D绘图支架与微孔股线的制造，用于骨组织工程。
支架孔隙度通过促进细胞附着，增殖和新骨形成的成骨分化，在旨在有效组织再生的骨组织工程中发挥了关键作用。三维绘图系统（3DPS）已被广泛用于向支架引入孔隙。然而，在支架链中引入某些特征以改善骨组织再生仍然是一个挑战。在这项工作中，我们使用3DPS和非溶剂诱导的相分离方法制造了具有大孔和微孔结构特征的骨组织支架。这种方法允许在支架链中产生大孔和微孔。仔细表征了多孔支架的表面形态，机械性能和降解性能。将人类骨髓基质细胞培养在支架上，然后进行体外分析以评估支架的生物功能。高度多孔的支架表现出与松质骨相似的机械性能。与无孔支架相比，多孔支架中的细胞附着，增殖和分化明显更高。这些结果表明高度多孔的支架具有作为骨组织再生平台的巨大潜力。
更新日期：2020-02-13
中文翻译：
3D绘图支架与微孔股线的制造，用于骨组织工程。
支架孔隙度通过促进细胞附着，增殖和新骨形成的成骨分化，在旨在有效组织再生的骨组织工程中发挥了关键作用。三维绘图系统（3DPS）已被广泛用于向支架引入孔隙。然而，在支架链中引入某些特征以改善骨组织再生仍然是一个挑战。在这项工作中，我们使用3DPS和非溶剂诱导的相分离方法制造了具有大孔和微孔结构特征的骨组织支架。这种方法允许在支架链中产生大孔和微孔。仔细表征了多孔支架的表面形态，机械性能和降解性能。将人类骨髓基质细胞培养在支架上，然后进行体外分析以评估支架的生物功能。高度多孔的支架表现出与松质骨相似的机械性能。与无孔支架相比，多孔支架中的细胞附着，增殖和分化明显更高。这些结果表明高度多孔的支架具有作为骨组织再生平台的巨大潜力。
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