Rhodium(I)/Chiral Diene‐Catalyzed Enantioselective Addition of Boronic Acids to N‐Unsubstituted Isatin‐Derived Ketimines,Chemistry - An Asian Journal

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Rhodium(I)/Chiral Diene‐Catalyzed Enantioselective Addition of Boronic Acids to N‐Unsubstituted Isatin‐Derived Ketimines
Chemistry - An Asian Journal ( IF 3.5 ) Pub Date : 2020-01-24 , DOI: 10.1002/asia.201901745
Ryohei Yonesaki ₁ , Ibuki Kusagawa ₁ , Hiroyuki Morimoto ₁ , Tamio Hayashi ₂ , Takashi Ohshima ₁

Affiliation

Enantioselective addition of boronic acids to N‐unsubstituted isatin‐derived ketimines was realized using rhodium(I)/chiral diene catalysts. The reactions can be performed in the presence of catalytic amounts of a base to give adducts in high yield with high enantioselectivity. Preliminary mechanistic information including a computational model to explain the observed enantioselectivity is also provided.

中文翻译：

铑（I）/手性二烯催化的硼酸对N-未取代的靛蓝衍生的丁二胺酮的对映选择性加成

使用铑（I）/手性二烯催化剂实现了将硼酸对映选择性地添加到N-未取代的由靛红衍生的酮亚胺中。反应可以在催化量的碱存在下进行，以高收率和高对映选择性得到加合物。还提供了包括解释所观察到的对映选择性的计算模型在内的初步机械信息。

更新日期：2020-01-24

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