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Differences in Functional Connectivity Networks Related to the Midbrain Dopaminergic System-Related Area in Various Psychiatric Disorders.
Schizophrenia Bulletin ( IF 5.3 ) Pub Date : 2020-01-05 , DOI: 10.1093/schbul/sbz121
Yuko Nakamura 1, 2 , Naohiro Okada 3, 4 , Daisuke Koshiyama 3 , Kouhei Kamiya 5 , Osamu Abe 5 , Akira Kunimatsu 5, 6 , Kazuo Okanoya 1, 2, 4, 7 , Kiyoto Kasai 1, 2, 3, 4, 7 , Shinsuke Koike 1, 2, 3, 4, 7
Affiliation  

Disruptions in the dopamine system have been observed in psychiatric disorders. Since dopamine is mainly produced in the ventral tegmental area (VTA), elucidating the differences in the VTA neural network across psychiatric disorders would facilitate a greater understanding of the pathophysiological mechanisms underlying these disorders. However, no study has compared VTA-seed-based functional connectivity across psychiatric disorders. Therefore, we conducted a resting-state functional magnetic resonance imaging (rs-fMRI) study to perform a seed-based fMRI analysis, using the VTA as a seed.

中文翻译:


各种精神疾病中与中脑多巴胺能系统相关区域相关的功能连接网络的差异。



在精神疾病中观察到多巴胺系统的破坏。由于多巴胺主要在腹侧被盖区(VTA)产生,阐明不同精神疾病中 VTA 神经网络的差异将有助于更好地了解这些疾病背后的病理生理机制。然而,还没有研究比较基于 VTA 种子的精神疾病的功能连接。因此,我们进行了静息态功能磁共振成像 (rs-fMRI) 研究,使用 VTA 作为种子进行基于种子的 fMRI 分析。
更新日期:2020-01-05
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