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High expression of chaperonin-containing TCP1 subunit 3 may induce dismal prognosis in multiple myeloma.
The Pharmacogenomics Journal ( IF 2.9 ) Pub Date : 2020-01-06 , DOI: 10.1038/s41397-019-0145-6 Tingting Qian 1, 2 , Longzhen Cui 3, 4 , Yan Liu 3, 4 , Zhiheng Cheng 5 , Liang Quan 1, 2 , Tiansheng Zeng 6 , Wenhui Huang 1, 2 , Yifeng Dai 5 , Jinghong Chen 2 , Ling Liu 1 , Jingqi Chen 2 , Ying Pang 1 , Guangsheng Wu 7 , Xu Ye 1 , Jinlong Shi 8 , Lin Fu 1, 2, 3, 4 , Chaozeng Si 9
The Pharmacogenomics Journal ( IF 2.9 ) Pub Date : 2020-01-06 , DOI: 10.1038/s41397-019-0145-6 Tingting Qian 1, 2 , Longzhen Cui 3, 4 , Yan Liu 3, 4 , Zhiheng Cheng 5 , Liang Quan 1, 2 , Tiansheng Zeng 6 , Wenhui Huang 1, 2 , Yifeng Dai 5 , Jinghong Chen 2 , Ling Liu 1 , Jingqi Chen 2 , Ying Pang 1 , Guangsheng Wu 7 , Xu Ye 1 , Jinlong Shi 8 , Lin Fu 1, 2, 3, 4 , Chaozeng Si 9
Affiliation
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The prognosis role of CCT3 in MM and the possible pathways it involved were studied in our research. By analyzing ten independent datasets (including 48 healthy donors, 2220 MM, 73 MGUS, and 6 PCL), CCT3 was found to express higher in MM than healthy donors, and the expression level was gradually increased from MGUS, SMM, MM to PCL (all P < 0.01). By analyzing three independent datasets (GSE24080, GSE2658, and GSE4204), we found that CCT3 was a significant indicator of poor prognosis (all P < 0.01). KEGG and GSEA analysis showed that CCT3 expression was associated with JAK-STAT3 pathway, Hippo signaling pathway, and WNT signaling pathway. In addition, different expressed genes analysis revealed MYC, which was one of the downstream genes regulated by JAK-STAT3 pathway, was upregulated in MM. This confirms that JAK-STAT3 signaling pathway may promote the progress of disease which was regulated by CCT3 expression. Our study revealed that CCT3 may play a supporting role at the diagnosis of myeloid, and high expression of CCT3 suggested poor prognosis in MM. CCT3 expression may promote the progression of MM mainly by regulating MYC through JAK-STAT3 signaling pathway.
中文翻译：
含有伴侣蛋白的TCP1亚基3的高表达可能会诱发多发性骨髓瘤预后不良。
在我们的研究中，研究了CCT3在MM中的预后作用及其可能的通路。通过分析10个独立的数据集（包括48个健康供体，2220 MM，73 MGUS和6个PCL），发现CCT3在MM中的表达高于健康供体，并且表达水平从MGUS，SMM，MM到PCL逐渐增加（所有P <0.01）。通过分析三个独立的数据集（GSE24080，GSE2658和GSE4204），我们发现CCT3是不良预后的重要指标（所有P <0.01）。KEGG和GSEA分析表明CCT3表达与JAK-STAT3途径，Hippo信号途径和WNT信号途径相关。此外，不同表达基因的分析显示，MYC是受JAK-STAT3途径调控的下游基因之一，在MM中被上调。这证实JAK-STAT3信号传导途径可以促进由CCT3表达调节的疾病进展。我们的研究表明，CCT3可能在髓样的诊断中起辅助作用，CCT3的高表达提示MM预后不良。CCT3表达可能主要通过通过JAK-STAT3信号通路调节MYC来促进MM的发展。
更新日期：2020-01-06
中文翻译：
含有伴侣蛋白的TCP1亚基3的高表达可能会诱发多发性骨髓瘤预后不良。
在我们的研究中，研究了CCT3在MM中的预后作用及其可能的通路。通过分析10个独立的数据集（包括48个健康供体，2220 MM，73 MGUS和6个PCL），发现CCT3在MM中的表达高于健康供体，并且表达水平从MGUS，SMM，MM到PCL逐渐增加（所有P <0.01）。通过分析三个独立的数据集（GSE24080，GSE2658和GSE4204），我们发现CCT3是不良预后的重要指标（所有P <0.01）。KEGG和GSEA分析表明CCT3表达与JAK-STAT3途径，Hippo信号途径和WNT信号途径相关。此外，不同表达基因的分析显示，MYC是受JAK-STAT3途径调控的下游基因之一，在MM中被上调。这证实JAK-STAT3信号传导途径可以促进由CCT3表达调节的疾病进展。我们的研究表明，CCT3可能在髓样的诊断中起辅助作用，CCT3的高表达提示MM预后不良。CCT3表达可能主要通过通过JAK-STAT3信号通路调节MYC来促进MM的发展。
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