Pharmaceutical pollution has gained attention with the development of analytical technology. The occurrence of 91 pharmaceutically active compounds from variety of drug groups including pain killers, antimicrobials, cardiovascular drugs, hypolipidemic drugs, central nervous system drugs, and stimulants was investigated in Ceyhan River, Turkey. Pharmaceutically active compounds were examined at 9 stations, seasonally during the periods of September 2013–August 2014. For the pharmaceutically active compound analysis, solid phase extraction (SPE) method was used and measured by using liquid chromatography tandem mass spectrometry (LC-MS/MS). Highest measured pharmaceutically active compound concentration was caffeine (4880.00 ng/L). Other high concentrated pharmaceuticals were diazepam (374.00 ng/L), gabapentin (355.00 ng/L), lidocaine (48.70 ng/L), etodolac (47.35 ng/L), metoprolol (43.60 ng/L), carbamazepine (24.25 ng/L), diclofenac (17.60 ng/L), and fluconazole (15.95 ng/L). Carbamazepine and lidocaine were the most frequently detected pharmaceutics in the river water. The results of risk assessment shows that risk quotient values (RQs) is lower than 0.01, except sertraline, which means that most of the detected pharmaceutically active compounds pose no environmental risk to aquatic environment in Ceyhan River. However, it is not possible to give precise information about the effects of all detected pharmaceutically active compounds when they behave together in the aquatic environment.

随着分析技术的发展，药物污染受到关注。在土耳其的Ceyhan河中调查了91种药物活性化合物的产生，这些化合物来自各种药物，包括止痛药，抗微生物药，心血管药物，降血脂药，中枢神经系统药和兴奋剂。在2013年9月至2014年8月期间，按季节在9个站点进行了药物活性化合物检查。对于药物活性化合物分析，使用固相萃取（SPE）方法并通过液相色谱串联质谱法（LC-MS /多发性硬化症）。最高的药物活性化合物浓度是咖啡因（4880.00 ng / L）。其他高浓度药物是地西epa（374.00 ng / L），加巴喷丁（355.00 ng / L），利多卡因（48.70 ng / L），依托度酸（47.35 ng / L），美托洛尔（43.60 ng / L），卡马西平（24.25 ng / L），双氯芬酸（17.60 ng / L）和氟康唑（15.95 ng / L）。卡马西平和利多卡因是河水中最常检测到的药物。风险评估结果表明，除舍曲林外，风险商值（RQs）均低于0.01，这意味着大多数检测到的药物活性化合物对杰伊汉河的水生环境没有环境风险。但是，不可能给出有关所有检测到的药物活性化合物在水生环境中共同作用时的作用的准确信息。卡马西平和利多卡因是河水中最常检测到的药物。风险评估结果表明，除舍曲林外，风险商值（RQs）均低于0.01，这意味着大多数检测到的药物活性化合物对杰伊汉河的水生环境没有环境风险。但是，不可能给出有关所有检测到的药物活性化合物在水生环境中共同作用时的作用的准确信息。卡马西平和利多卡因是河水中最常检测到的药物。风险评估结果表明，除舍曲林外，风险商值（RQs）均低于0.01，这意味着大多数检测到的药物活性化合物对杰伊汉河的水生环境没有环境风险。但是，不可能给出有关所有检测到的药物活性化合物在水生环境中共同作用时的作用的准确信息。