Synthesis of Pashinintide A, a Natural Cyclic Hexapeptide Supposedly Capable of Forming a Complex with Sucrose,Asian Journal of Organic Chemistry

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Synthesis of Pashinintide A, a Natural Cyclic Hexapeptide Supposedly Capable of Forming a Complex with Sucrose
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2020-01-02 , DOI: 10.1002/ajoc.201900663
Xuejian Yin ₁ , Wei Li ₂ , Biao Yu ₁

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Pashinintide A, a cyclic hexapeptide discovered from Pyrus pashia, has been synthesized in a linear sequence of 8 steps and 24% overall yield from N‐Boc glycine, featuring a convergent [3+3] fragment coupling strategy. Although the structure of the synthetic Pashinintide A was unambiguously confirmed by X‐ray diffraction analysis, its proposed complexation with sucrose cannot be validated.

中文翻译：

Pashinintide A的合成，它是天然的环状六肽，据信能够与蔗糖形成复合物

Pashinintide A是一种从Pyrus pashia中发现的环状六肽，它以8步的线性顺序合成，N- Boc甘氨酸的总收率为24％，具有收敛的[3 + 3]片段偶联策略。尽管合成的Pashinintide A的结构已通过X射线衍射分析明确证实，但其与蔗糖的络合作用无法得到验证。

更新日期：2020-01-02

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