Thermo-responsive block copolymers are of great interest in biomedical and nanotechnological fields. These polymers achieve a versatile and complex responsiveness through a sophisticated and intricate combination of different thermo-responsive blocks. While their utility is clear, the fundamental design principles of such vinyl polymers are not yet thoroughly understood. Herein, a precise synthesis of sequence-controlled amino-acid-derived vinyl polymers and their unique thermal response in water are reported. Seven distinct block (random) copolymers that contain two kinds of amino acid blocks (poly(N-acryloyl alanine(A)- or glycine(G)-methyl ester)) with the same total chain length (degree of polymerization [DP] ≈30) and chemical composition (A/G ≈1), but with systematic variations in the block sequence and length, with an accuracy target of DP ± 1, are prepared. By specifying the primary structure, the thermal responses including transition temperature, thermo-sensitivity, and microenvironment in the dehydrated state can be finely tuned. These findings offer new directions in the design of structurally and functionally diverse thermo-responsive vinyl polymers.

中文翻译：

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精确合成的序列控制氨基酸衍生的乙烯基聚合物：热响应聚合物设计的新见解。

热响应性嵌段共聚物在生物医学和纳米技术领域中非常受关注。这些聚合物通过将不同的热响应性嵌段进行复杂而复杂的组合，来实现通用而复杂的响应性。尽管它们的用途很明确，但这种乙烯基聚合物的基本设计原理尚未完全理解。在此，报道了由序列控制的氨基酸衍生的乙烯基聚合物的精确合成及其在水中的独特热响应。七种不同的嵌段（无规）共聚物，包含两种氨基酸嵌段（聚（N-丙烯酰基丙氨酸（A）-或甘氨酸（G）-甲基酯）），并且具有相同的总链长（聚合度[DP]） 30）和化学成分（A / G≈1），但在嵌段序列和长度上存在系统性变化，准备的目标精度为DP±1。通过指定主要结构，可以微调包括转变温度，热敏性和处于脱水状态的微环境在内的热响应。这些发现为结构和功能多样的热响应性乙烯基聚合物的设计提供了新的方向。