Facile Fabrication of Redox-Responsive Covalent Organic Framework Nanocarriers for Efficiently Loading and Delivering Doxorubicin.,Macromolecular Rapid Communications

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Facile Fabrication of Redox-Responsive Covalent Organic Framework Nanocarriers for Efficiently Loading and Delivering Doxorubicin.
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2020-01-01 , DOI: 10.1002/marc.201900570
Shuai Liu ₁ , Jumin Yang ₁ , Ruiwei Guo ₁ , Liandong Deng ₁ , Anjie Dong ₁ , Jianhua Zhang _{1,

2}

Affiliation

Covalent organic frameworks (COFs) as drug delivery systems have shown great promise, but their pharmaceutical applications are often limited by complex building blocks, tedious preparations, irregular shape, and uncontrolled drug release within target cells. Herein, a facile strategy is developed to prepare PEGylated redox-responsive nanoscale COFs (denoted F68@SS-COFs) for efficiently loading and delivering doxorubicin (DOX) by use of FDA-approved Pluronic F68 and commercially available building blocks. The obtained F68@SS-COFs with controlled size, high stability, and good biocompatibility can not only achieve a very high DOX-loading content (about 21%) and very low premature leakage at physiological condition but can also rapidly respond to the tumor intracellular microenvironment and efficiently release DOX to kill tumor cells. Considering the readily available raw materials, simple preparation process, and desirable redox-responsiveness, the strategy provided here opens up a promising avenue to develop well-defined COFs-based nanomedicines for cancer therapy.

中文翻译：

氧化还原反应性共价有机框架纳米载体的制备，可有效负载和传递阿霉素。

共价有机框架（COF）作为药物递送系统已显示出巨大的希望，但其药物应用通常受制于复杂的组成部分，繁琐的制剂，形状不规则以及靶细胞内药物释放不受控制的限制。本文中，开发了一种简便的策略来制备聚乙二醇化的氧化还原响应纳米级COF（表示为F68 @ SS-COF），以通过使用FDA批准的Pluronic F68和市售构建基块有效地装载和输送阿霉素（DOX）。获得的F68 @ SS-COFs具有可控的尺寸，高的稳定性和良好的生物相容性，不仅可以在生理条件下达到很高的DOX负载量（约21％）和非常低的过早渗漏，而且还可以快速响应肿瘤细胞内微环境并有效释放DOX以杀死肿瘤细胞。

更新日期：2020-01-02

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