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Lumbar vertebral osteoradionecrosis: a rare case report with 10-year follow-up and brief literature review.
BMC Musculoskeletal Disorders ( IF 2.2 ) Pub Date : 2020-01-04 , DOI: 10.1186/s12891-019-3024-z
Cong Jin 1 , Minghua Xie 1 , Wengqing Liang 1 , Yu Qian 1
Affiliation  

BACKGROUND Osteoradionecrosis (ORN) is a complication that occurs after radiotherapy for head or neck malignancies. ORN of the spine is rare, with only few cases affecting the cervical spine reported to date. To our knowledge, no case of lumbar ORN has been reported. We report a rare case of ORN in the lumbar spine that occurred 2 years after radiotherapy and perform a literature review. CASE PRESENTATION We present a case of lumbar ORN that occurred 2 years after radiotherapy for gallbladder carcinoma. The patient was successfully treated conservatively and followed up for > 10 years. CONCLUSIONS ORN of the spine is a rare complication of radiotherapy. Spinal ORN is clinically described as a chronic disease with a slow onset. The most common presenting symptom of spinal ORN is pain. However, as ORN progresses, spinal kyphosis and instability can lead to neurological compression and thus to induced myelopathy or radiculopathy. Treatment of spinal ORN is comprehensive, including orthosis, medication, hyperbaric oxygen therapy, surgery, and new treatment combinations of pentoxifylline and tocopherol. The surgical rate for spinal ORN is relatively high.

中文翻译:

腰椎骨放射性坏死:罕见病例报告,为期10年的随访和简要文献复习。

背景技术骨放射性坏死(ORN)是放疗后发生的头或颈恶性肿瘤的并发症。脊柱的ORN很少见,迄今只有少数病例影响到颈椎。据我们所知,尚无腰椎ORN病例的报道。我们报告了放疗后2年发生的罕见的腰椎ORN病例,并进行了文献复习。病例介绍我们介绍了一个发生在胆囊癌放疗后2年的腰部ORN病例。该患者经过保守治疗成功,随访时间超过10年。结论脊柱ORN是一种罕见的放疗并发症。脊柱ORN在临床上被描述为起病缓慢的慢性疾病。脊柱ORN最常见的症状是疼痛。但是,随着ORN的发展,脊柱后凸和不稳定会导致神经系统受压,从而导致脊髓病或神经根病。脊柱ORN的治疗是全面的,包括矫形,药物治疗,高压氧治疗,手术以及己酮可可碱和生育酚的新疗法组合。脊柱ORN的手术率较高。
更新日期:2020-01-04
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