Enantioselective (3+2) cycloaddition via N-heterocyclic carbene-catalyzed addition of homoenolates to cyclic N-sulfonyl trifluoromethylated ketimines: synthesis of fused N-heterocycle γ-lactams.,Chemical Communications

当前位置： X-MOL 学术 › Chem. Commun. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Enantioselective (3+2) cycloaddition via N-heterocyclic carbene-catalyzed addition of homoenolates to cyclic N-sulfonyl trifluoromethylated ketimines: synthesis of fused N-heterocycle γ-lactams.
Chemical Communications ( IF 4.3 ) Pub Date : 2020-01-13 , DOI: 10.1039/c9cc09269b
Zhen-Zhen Zhang ₁ , Yongna Zhang , Hui-Xin Duan , Zhuo-Fei Deng , You-Qing Wang

Affiliation

An enantioselective (3+2) cycloaddition of enals and cyclic N-sulfonyl trifluoromethyl ketimines via N-heterocyclic carbene-catalyzed homoenolate addition is described. This reaction can efficiently construct fused N-heterocycle γ-lactams bearing two adjacent chiral centers with >20 : 1 dr and 94-99% ee, with one chiral center as a trifluoromethylated α-tetrasubstituted carbon stereocenter.

中文翻译：

通过将N-杂环卡宾催化的均烯酸酯加成到环状N-磺酰基三氟甲基化酮亚胺上的对映选择性（3 + 2）环加成反应：稠合的N杂环γ-内酰胺的合成。

描述了通过N-杂环卡宾催化的均烯酸酯加成对映体和环状N-磺酰基三氟甲基酮亚胺的对映选择性（3 + 2）环加成。该反应可以有效地构建稠合的N-杂环γ-内酰胺，其带有两个相邻的手性中心，具有> 20：1 dr和94-99％ee，一个手性中心为三氟甲基化的α-四取代碳立体中心。

更新日期：2020-01-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11