Spinal cord injury (SCI) is a serious trauma, which often results in a permanent loss of motor and sensory functions, pain and spasticity. Despite extensive research, there is currently no available therapy that would restore the lost functions after SCI in human patients. Advanced treatments use regenerative medicine or its combination with various interdisciplinary approaches such as tissue engineering or biophysical methods. This review summarizes and critically discusses the research from specific interdisciplinary fields in SCI treatment such as the development of biomaterials as scaffolds for tissue repair, and using a magnetic field for targeted cell delivery. We compare the treatment effects of synthetic non-degradable methacrylate-based hydrogels and biodegradable biological scaffolds based on extracellular matrix. The systems using magnetic fields for magnetically guided delivery of stem cells loaded with magnetic nanoparticles into the lesion site are then suggested and discussed.

脊髓损伤（SCI）是一种严重的创伤，通常会导致运动和感觉功能，疼痛和痉挛的永久丧失。尽管进行了广泛的研究，但目前尚无可用于恢复人类患者SCI后丧失功能的治疗方法。先进疗法使用再生医学或将其与各种跨学科方法（例如组织工程或生物物理方法）结合使用。这篇综述总结并批判性地讨论了来自SCI治疗的特定跨学科领域的研究，例如开发生物材料作为组织修复的支架，以及利用磁场进行靶细胞递送。我们比较了基于细胞外基质的合成不可降解的甲基丙烯酸酯基水凝胶和可生物降解的生物支架的治疗效果。