Objective

Adjuvant endocrine therapy (AET) reduces the risk of recurrence and mortality in women with hormone receptor–positive breast cancer. However, adherence to AET remains suboptimal. Women’s beliefs about medication have been associated with medication adherence. The purpose of this study was to identify multilevel factors associated with women’s beliefs about AET.

Methods

Beliefs about AET, measured using the Belief about Medicines Questionnaire (BMQ), sociodemographic (e.g., age), psychosocial (e.g., religiosity), and healthcare factors (e.g., patient-provider communication), were collected via survey. Clinical data were abstracted from medical records. Two stepwise regression analyses models were performed to assess relationships between variables and necessity and concern beliefs.

Results

In our sample of 572 women, mean BMQ concern score was 11.19 and mean necessity score was 13.85 (range 5–20). In the regression models, higher ratings of patient-provider communication were associated with lower concern and higher necessity beliefs. Higher concern beliefs were related to more AET-related symptoms (Β = 0.08; 95% CI 0.06 to 0.10; p < 0.001), lower patient satisfaction (Β = − 0.07; 95% CI − 0.09 to − 0.04; p < 0.001), and higher religiosity (Β = 0.05; 95% CI 0.01 to 0.08; p = 0.007). Higher necessity beliefs were associated with prior chemotherapy use (Β = 0.11; 95% CI 0.06 to 0.16; p < 0.005) and less education (Β = 1.00; 95% CI 0.27 to 1.73; p = 0.008).

Conclusions

Modifiable factors are related to women’s AET beliefs. Healthcare interactions may play a key role with regard to shaping women’s beliefs about their AET medication.

中文翻译：

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社会人口学、临床、社会心理和医疗保健相关因素与乳腺癌幸存者对辅助内分泌治疗的信念相关。

 客观的

辅助内分泌治疗（AET）可降低激素受体阳性乳腺癌女性的复发和死亡风险。然而，AET 的依从性仍然不理想。女性对药物的信念与药物依从性有关。本研究的目的是确定与女性 AET 信念相关的多层次因素。

 方法

通过调查收集对 AET 的信念，使用药物信念问卷 (BMQ)、社会人口统计学（例如年龄）、社会心理（例如宗教信仰）和医疗保健因素（例如患者与提供者的沟通）来衡量。临床数据是从病历中提取的。进行了两个逐步回归分析模型来评估变量与必要性和关注信念之间的关系。

 结果

在我们的 572 名女性样本中，平均 BMQ 关注得分为 11.19，平均必要性得分为 13.85（范围 5-20）。在回归模型中，较高的患者与提供者沟通评级与较低的担忧和较高的必要性信念相关。较高的担忧信念与更多的 AET 相关症状（ Β = 0.08；95% CI 0.06 至 0.10； p < 0.001）、较低的患者满意度相关（ Β = − 0.07；95% CI − 0.09 至 − 0.04； p < 0.001） ，以及更高的宗教信仰（ Β = 0.05；95% CI 0.01 至 0.08； p = 0.007）。较高的必要性信念与既往化疗使用（ Β = 0.11；95% CI 0.06 至 0.16； p < 0.005）和教育程度较低（ Β = 1.00；95% CI 0.27 至 1.73； p = 0.008）相关。

 结论

可改变的因素与女性的 AET 信念有关。医疗保健互动可能在塑造女性对其 AET 药物的信念方面发挥关键作用。