There are few data available on the prevalence of hyperuricemia and its possible association with cardiovascular diseases among the very elderly population. The main part of this study enrolled 320 very elderly hospitalized patients (aged 86.4 ± 5.0 years; females, 78.1%; males, 21.9%) with coronary artery disease (CAD) and arterial hypertension (AH). The second part of the study involved 48 patients younger than 60 years, who were hospitalized with CAD diagnosis for coronary angiography study. Patients with gout were excluded from analysis. Hyperuricemia was defined as serum uric acid (SUA) more than 340 μmol/l in women and 420 μmol/l in men. Elevated serum uric acid (SUA) levels were detected in 37.4% of 320 elderly patients. Hyperuricemia was significantly more common in women (in 41.5% of cases) than in men (in 25%) (p = 0.02). In the group of very elderly patients, there was a clear correlation between hyperuricemia and clinically significant chronic heart failure (OR = 5.0; 95% CI = 2.4–10.7; p < 0.0001), as well as with stroke in history (OR = 1.9; 95% CI = 1.0–3.4; p = 0.03). Hyperuricemia remained significant risk factor of heart failure in the multiple regression analysis (p < 0.001). Atrial fibrillation was significantly more frequently diagnosed in patients with hyperuricemia compared with patients with normal levels of uric acid (OR = 2.2; 95% CI = 1.3–3.6; p = 0.001). A pronounced positive correlation was found between the SUA levels and the diameter of the left atrium (r = 0.3; p = 0.000003). In the group of 48 CAD patients under 60 years of age, hyperuricemia was significantly associated with myocardial infarction (OR = 8.8; 95% CI = 2.0–38.9; p = 0.002) and chronic heart failure (OR = 6.9; 95% CI = 1.8–26.3; p = 0.003). In general, the obtained results indicate a significant prevalence of hyperuricemia in people with CAD. A significant relationship between the increased SUA levels and the development of some cardiovascular diseases was found.

中文翻译：

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高龄冠心病患者的高尿酸血症和心血管疾病

在极老的人群中，关于高尿酸血症的患病率及其与心血管疾病的关系的数据很少。该研究的主要部分招募了320名极老的住院患者（年龄86.4±5.0岁；女性78.1％；男性21.9％）患有冠心病（CAD）和动脉高压（AH）。该研究的第二部分涉及48位60岁以下的患者，他们接受了CAD诊断以进行冠状动脉造影研究。痛风患者被排除在分析之外。高尿酸血症的定义是女性的血清尿酸（SUA）大于340μmol/ l，男性的血浆尿酸超过420μmol/ l。在320名老年患者中，有37.4％的人血清尿酸（SUA）水平升高。女性（41.5％的病例）高尿酸血症的发生率明显高于男性（25％的病例）（p = 0.02）。在非常年老的患者组中，高尿酸血症与临床上显着的慢性心力衰竭之间存在明显的相关性（OR = 5.0； 95％CI = 2.4-10.7；p  <0.0001），以及与历史卒中（OR = 1.9） ； 95％CI = 1.0–3.4；p  = 0.03）。在多元回归分析中，高尿酸血症仍然是心力衰竭的重要危险因素（p  <0.001）。与尿酸水平正常的患者相比，高尿酸​​血症患者的房颤诊断频率更高（OR = 2.2； 95％CI = 1.3–3.6；p  = 0.001）。在SUA水平和左心房直径之间发现明显的正相关（r  = 0.3; p = 0.000003）。在48位60岁以下的CAD患者中，高尿酸血症与心肌梗塞（OR = 8.8; 95％CI = 2.0-38.9; p  = 0.002）和慢性心力衰竭（OR = 6.9; 95％CI = 1.8–26.3；p  = 0.003）。通常，所获得的结果表明CAD患者的高尿酸血症发生率很高。SUA水平升高与某些心血管疾病的发展之间存在显着的关系。