Obstructive sleep apnea (OSA) is a common sleep disorder affecting high proportion of the population. This disorder is associated with an increase in the oxidative stress and cardiovascular disease. Paraoxonase (PON) is a lipolactonase enzyme removing toxic lipids and decreasing lipoprotein oxidation. The present study was conducted to reassess possible alternation of PON activities in OSA patients. Studies measured PON activities in OSA were searched in PubMed, Scopus, EMBASE, Web of Science databases, and Cochrane Library from January 1990 to February 2019. Screening of the studies was performed by two authors independently according to title, abstract, and full text. Quality of studies was assessed by Newcastle-Ottawa Quality Assessment Scale, and random-effect model was used for evaluating the effect of OSA on PON activities. A total of 97 records were found in searching, 39 duplicated records were removed, and 5 studies for PON activity and 2 studies for aryl-esterase (ARE) activity were included in the meta-analysis. Pooled analysis showed no significant difference in terms of PON activity between OSA and control groups (p = 0.434). Similarly, ARE demonstrated no significant difference between OSA and control groups (p = 0.515). Subgroup meta-analysis according to age, BMI, AHI, and diagnosis criteria demonstrated no significant difference between two groups. The results of this study indicated no association between OSA and PON activities as an antioxidant enzyme. However, a relatively low number of studies limited us to conclude a definite conclusion; therefore, more studies are needed in this regard.

中文翻译：

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阻塞性睡眠呼吸暂停患者对氧磷酶活性的系统评价和荟萃分析

阻塞性睡眠呼吸暂停（OSA）是一种常见的睡眠障碍，会影响高比例的人群。这种疾病与氧化应激和心血管疾病的增加有关。对氧磷酶（PON）是一种脂内酰胺酶，可去除有毒脂质并减少脂蛋白氧化。进行本研究是为了重新评估OSA患者中PON活动的可能改变。从1990年1月至2019年2月在PubMed，Scopus，EMBASE，Web of Science数据库和Cochrane图书馆中搜索了OSA中测量的PON活动的研究。由两位作者分别根据标题，摘要和全文进行了研究筛选。通过纽卡斯尔-渥太华质量评估量表评估研究质量，并使用随机效应模型评估OSA对PON活性的影响。总共搜索到97条记录，删除了39条重复记录，荟萃分析包括5项关于PON活性的研究和2项关于芳基酯酶（ARE）活性的研究。汇总分析显示OSA与对照组之间在PON活性方面无显着差异（p  = 0.434）。同样，ARE也显示OSA与对照组之间无显着差异（p  = 0.515）。根据年龄，BMI，AHI和诊断标准进行的亚组荟萃分析表明，两组之间无显着差异。这项研究的结果表明OSA和PON作为抗氧化酶的活性之间没有关联。但是，相对较少的研究限制了我们得出明确的结论。因此，在这方面需要更多的研究。