Intraventricular hemorrhage (IVH) often occurs in preterm infants and is an important cause of brain damage in the infants. Although its incidence has decreased, IVH remains a significant complication in the survival of preterm infants. One of the predisposing factors is thyroid function. The aim of the present study was to evaluate the effects of thyroid hormones T4 and thyroid-stimulating hormone (TSH) on risk of IVH in Iranian preterm infants. We designed a cross-sectional study, and the population includes fifty preterm infants admitted in the neonatal intensive care unit (NICU) ward of Ali Asghar Hospital, Tehran, Iran, during the period of 2017 to 2018. Cranial sonography at the 5th and 30th day after birth was performed to evaluate the IVH and thyroid function tests were conducted on blood samples using radioimmunoassay. Results of IVH prevalence and grading indicated that 5th day IVH occurs in 38% and 30th day IVH occurs in 28% of infants. There is no statistically significant correlation between T4 and TSH with 5th day IVH but there is a significant statistical relationship between T4 and TSH levels and IVH on the 30th day after birth. Thyroid function hormones could be used as markers to predict the risk of IVH in preterm infants. Larger sample size can help to obtain more validated results.

中文翻译：

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甲状腺激素对早产儿脑室内出血风险的影响

脑室内出血（IVH）常发生在早产儿，是婴儿脑损伤的重要原因。尽管IVH的发生率下降了，但IVH仍然是早产儿生存中的重要并发症。诱发因素之一是甲状腺功能。本研究的目的是评估甲状腺激素T4和促甲状腺激素（TSH）对伊朗早产儿IVH风险的影响。我们设计了一项横断面研究，其人群包括2017年至2018年期间在伊朗德黑兰的阿里阿斯格哈医院新生儿重症监护病房（NICU）病房收治的五十名早产儿。5月和30日的颅骨超声检查在出生后第二天进行评估以评估IVH，并使用放射免疫分析法对血液样本进行甲状腺功能测试。IVH患病率和分级结果表明，有38％的婴儿发生了第5天的IVH，有28％的婴儿发生了第30天的IVH。出生后第30天，IVH时T4和TSH之间没有统计学上的显着相关性，但是出生后第30天T4和TSH水平与IVH之间有显着的统计关系。甲状腺功能激素可以用作预测早产儿IVH风险的标志物。较大的样本量可以帮助获得更多的验证结果。甲状腺功能激素可以用作预测早产儿IVH风险的标志物。较大的样本量可以帮助获得更多的验证结果。甲状腺功能激素可以用作预测早产儿IVH风险的标志物。较大的样本量可以帮助获得更多的验证结果。