Behçet’s syndrome (BS) is an autoimmune, rare, and severe multisystemic inflammatory disease characterized by recurrent oral aphthous ulcers, genital ulcers, skin lesions, and both anterior and posterior uveitis; articular, vascular, gastroenteric and neurological involvement may also occur. The multi-organ involvement and the wide range of clinical spectrum make the diagnosis of BS challenging. As other systemic chronic diseases, BS can affect all aspects of patients’ life, including sexual dysfunction (SD). So far, SD has been deeply studied among patients affected by many rheumatic diseases; however, little is known about the prevalence and the characteristics of SD among BS patients. The present work was aimed at providing a systematic literature review of the literature published on SD and BS. We carried out a systematic search in PubMed and Scopus based on controlled terms (MeSH) and keywords to identify literature data on SD in BS. The systematic search was independently performed by two clinicians based on the controlled medical subject heading terms for Behcet syndrome and SD. Systematic database search identified 32 records. Screening by title and abstract was then conducted and a total of 10 articles were eligible for full text assessment, five studies explored SD in male patients with BS, 3 studies in females and 2 works reported data on both genders. Globally, the systematic literature review results have underlined that SD seems frequent in BS patients. Both female and male patients experienced a significant correlation between SD and depression. The studies investigating sexuality in BS seem to demonstrate that in these patients SD may be mainly related to depression rather than to active organic manifestations.

中文翻译：

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贝塞综合症的性功能障碍

贝塞综合症（BS）是一种自身免疫性，罕见且严重的多系统性炎症性疾病，其特征是复发性口腔口疮，生殖器溃疡，皮肤病变以及前，后葡萄膜炎。也可能发生关节，血管，胃肠和神经系统受累。多器官参与和广泛的临床范围使BS的诊断具有挑战性。与其他系统性慢性疾病一样，BS会影响患者生活的方方面面，包括性功能障碍（SD）。到目前为止，对患有多种风湿病的患者进行了深入的研究。然而，关于BS患者中SD的患病率和特征知之甚少。当前的工作旨在对SD和BS上发表的文献进行系统的文献综述。我们根据控制词（MeSH）和关键字对PubMed和Scopus进行了系统搜索，以识别BS中SD的文献数据。系统搜索是由两名临床医生根据Behcet综合征和SD的受控医学主题词独立进行的。系统的数据库搜索确定了32条记录。然后按标题和摘要进行筛选，共有10篇文章符合全文评估的条件，其中5项研究探讨了BS男性患者的SD，3项针对女性的研究以及2项报道了这两种性别的数据。在全球范围内，系统的文献综述结果强调了BS患者似乎SD频发。女性和男性患者都经历了SD和抑郁之间的显着相关性。