Abstract

Although a perturbed cerebral blood flow (CBF) has been reported in patients with Wernicke’s encephalopathy (WE), its clinical meaning is still elusive. A retrospective analysis of 10 patients (male, 6; mean age, 57.7 years) with WE between October 2012 and May 2018 was performed. Brain imaging was performed using fluid-attenuated inversion recovery (FLAIR), diffusion-weighted imaging (DWI), arterial spin labeling (ASL) perfusion-weighted imaging (PWI), and contrasted enhanced T1-weighted imaging. All patients had symmetric high signal intensity lesions in the vulnerable areas on FLAIR or DWI with focal hyperintensity on ASL-PWI (100% sensitivity). CBF_lesion was variable (from 70 mL/100 g/min to 190.0 mL/100 g/min). CBF_lesion/CBF_{white matter} was elevated, ranging from 2.5 to 5.5. Focal hyperintensity on ASL in the vulnerable areas can be a diagnostic clue for WE.

中文翻译：

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Wernicke脑病的局灶性充血：动脉自旋标记MRI初步研究

摘要

尽管已经报道了Wernicke脑病（WE）患者的脑血流（CBF）紊乱，但其临床意义仍然难以捉摸。回顾性分析了2012年10月至2018年5月期间发生的10例WE患者（男性，6例，平均年龄57.7岁）。脑成像使用液衰减倒置恢复（FLAIR），扩散加权成像（DWI），动脉旋转标记（ASL）灌注加权成像（PWI）和对比增强的T1加权成像进行。所有患者均在FLAIR或DWI的脆弱区域出现对称的高信号强度病变，而ASL-PWI则出现局灶性高信号（敏感性为100％）。CBF_病变是可变的（从70 mL / 100 g / min到190.0 mL / 100 g / min）。CBF_病变/ CBF_白质升高，范围从2.5到5.5。脆弱地区ASL上的局灶性高血压可能是WE的诊断线索。