Abstract

Currently, the treatment of infections by Staphylococcus epidermidis (S. epidermidis) represents a challenge because some strains have multidrug-resistance to antimicrobial products (antibiotic and biocides) and can produce biofilms. These biofilms protect bacterial cells from both antimicrobials and the host immune response. Therefore, it is crucial to encourage research on the development of new treatments. One method is immunotherapy, targeting components of S. epidermidis, such as S. epidermidis surface (Ses) proteins. Ses is expressed constitutively in most strains, and they participate in biofilm formation. This review is an update on Ses, regarding their structure, biological function, their relationship with S. epidermidis biofilm formation, and its possible role as therapeutic targets to develop immunotherapeutic treatments to prevent infections by S. epidermidis.

中文翻译：

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表皮葡萄球菌细胞壁锚定蛋白概述：抑制生物膜形成的潜在目标

摘要

目前，表皮葡萄球菌（S. epidermidis）感染的治疗面临挑战，因为某些菌株对抗菌产品（抗生素和杀生物剂）具有多药耐药性，并且可以产生生物膜。这些生物膜可保护细菌细胞免受抗菌剂和宿主免疫反应的影响。因此，至关重要的是鼓励对新疗法的开发进行研究。一种方法是免疫疗法，靶向表皮葡萄球菌的成分，例如表皮葡萄球菌表面（Ses）蛋白。Ses在大多数菌株中组成性表达，它们参与生物膜的形成。这篇评论是关于Ses的最新信息，涉及它们的结构，生物学功能以及它们与Ses的关系。表皮葡萄球菌生物膜的形成及其可能的作用，作为开发免疫治疗方法以预防表皮葡萄球菌感染的治疗靶标。