PURPOSE To analyze the foveal avascular zone (FAZ) in patients with diabetes and no retinopathy vs. controls using OCT angiography (OCT-A). METHODS Prospective, observational clinical study. Type I and II diabetics with no retinopathy and healthy control patients underwent OCT-A. The FAZ size and capillary density were calculated using Image J and Adobe Photoshop CS8. Statistical analysis was performed using one-way ANOVA with Tukey's multiple comparison test and the Pearson correlation test. RESULTS Fifty-two eyes of 28 diabetic patients and 28 eyes of 16 healthy controls were enrolled. Type I diabetes patients had a longer disease duration than type II (30.3 ± 10.3 vs. 12.3 ± 9.7 years). The mean superficial capillary plexus (SCP) of the FAZ area was 0.27 ± 0.1, 0.36 ± 0.14, and 0.27 ± 0.12 mm2, for the type I, type II, and controls (p = 0.0058) and was significantly larger in type II diabetics (p < 0.05). The mean DCP (deep capillary plexus) FAZ was significantly larger in type II diabetics vs. controls (0.67 ± 0.2 and 0.52 ± 0.16 mm2 respectively) (p < 0.05). Both type I and type II SCP capillary density were significantly lower than the controls (p < 0.05, p < 0.005), and DCP capillary density was significantly lower in type II vs. controls (p < 0.005). CONCLUSIONS Type I patients showed fewer changes in the FAZ than the type II group, although their duration of diabetes was longer. Larger studies are needed to better analyze the differences between type I and type II diabetics.

中文翻译：

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I型和II型糖尿病患者的中央凹脉管系统变化和非灌注，无糖尿病性视网膜病变的证据。

目的使用OCT血管造影术（OCT-A）分析无控制视网膜病变的糖尿病患者的黄斑中心凹血管区（FAZ）。方法前瞻性，观察性临床研究。没有视网膜病变的I型和II型糖尿病患者以及健康对照患者接受了OCT-A治疗。FAZ大小和毛细管密度使用Image J和Adobe Photoshop CS8计算。使用单向方差分析与Tukey的多重比较检验和Pearson相关检验进行统计分析。结果纳入了28例糖尿病患者的52眼和16例健康对照者的28眼。I型糖尿病患者的病程比II型更长（30.3±10.3 vs. 12.3±9.7年）。对于I型，II型和对照组，FAZ区域的平均表面毛细血管丛（SCP）分别为0.27±0.1、0.36±0.14和0.27±0.12 mm2（p = 0。0058），且在II型糖尿病患者中明显更大（p <0.05）。II型糖尿病患者的平均DCP（深层毛细血管丛）FAZ显着大于对照组（分别为0.67±0.2和0.52±0.16 mm2）（p <0.05）。I型和II型SCP毛细血管密度均显着低于对照组（p <0.05，p <0.005），而II型的DCP毛细血管密度显着低于对照组（p <0.005）。结论尽管糖尿病患者的病程更长，但I型患者的FAZ改变少于II型患者。需要进行更大的研究才能更好地分析I型和II型糖尿病之间的差异。分别为52±0.16 mm2）（p <0.05）。I型和II型SCP毛细血管密度均显着低于对照组（p <0.05，p <0.005），而II型的DCP毛细血管密度显着低于对照组（p <0.005）。结论尽管糖尿病患者的病程更长，但I型患者的FAZ改变少于II型患者。需要进行更大的研究才能更好地分析I型和II型糖尿病之间的差异。分别为52±0.16 mm2）（p <0.05）。I型和II型SCP毛细血管密度均显着低于对照组（p <0.05，p <0.005），而II型的DCP毛细血管密度显着低于对照组（p <0.005）。结论尽管糖尿病患者的病程更长，但I型患者的FAZ改变少于II型患者。需要进行更大的研究才能更好地分析I型和II型糖尿病之间的差异。尽管他们的糖尿病病程更长。需要进行更大的研究才能更好地分析I型和II型糖尿病之间的差异。尽管他们的糖尿病病程更长。需要进行更大的研究才能更好地分析I型和II型糖尿病之间的差异。