PURPOSE To provide an integrate multimodal imaging characterization of peripheral drusen in the eyes with and without macular signs of age-related macular degeneration (AMD) and to analyze their association with macular findings. METHODS In this retrospective, cross-sectional study, subjects with peripheral drusen were imaged with the Optos (Optos PLC, Dunfermline, Scotland, UK) and Spectralis devices to obtain referenced spectral domain optical coherence tomography (SD-OCT) images. Two experienced graders independently graded the ultra-widefield (UWF) pseudocolor and fundus autofluorescence (FAF) images for the presence of peripheral drusen and analyzed peripheral druse features using OCT. Main outcome measures included quantitative and qualitative assessment of peripheral drusen. RESULTS Fifty-seven eyes (30 subjects) were included in the analysis. Mean ± SD age was 77.6 ± 9.2 years (range 54-97 years). On pseudocolor images, graders identified the presence of drusen in all the enrolled eyes (Cohen's kappa was 1.0). On FAF images, Cohen's kappa was 0.71. In the topographical assessment, peripheral drusen were detected in 23 cases in the temporal region, in 40 cases in the nasal region, in 40 cases in the inferior region, and in 42 cases in the superior region. On SD-OCT images, peripheral drusen had a high reflective core in 97.1% of cases, while remaining drusen were characterized by a low reflective core. The macula was affected by early/intermediate AMD in 23 eyes (43.5%) and late AMD in 6 eyes (10.5%). CONCLUSIONS We provided an integrate multimodal imaging assessment of peripheral drusen in the eyes with and without AMD. Peripheral drusen were characterized by distinguished features that may suggest that these lesions constitute a distinct disease, rather than representing an expansion of AMD.

中文翻译：

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外周玻璃疣的多峰成像表征。

目的提供具有和不具有年龄相关性黄斑变性（AMD）的黄斑迹象的眼中周围玻璃膜疣的综合多模态成像特征，并分析其与黄斑发现的关系。方法在这项回顾性横断面研究中，使用Optos（Optos PLC，Dunfermline，苏格兰，英国）和Spectralis设备对周围玻璃膜疣患者进行成像，以获得参考光谱域光学相干断层扫描（SD-OCT）图像。两名经验丰富的分级员分别对超宽视场（UWF）伪色和眼底自发荧光（FAF）图像进行分级，以评估是否存在周围玻璃疣，并使用OCT分析了周围的玻璃疣特征。主要结果指标包括外周玻璃疣的定量和定性评估。结果分析中包括57只眼（30名受试者）。平均±SD年龄为77.6±9.2岁（范围54-97岁）。在伪彩色图像上，分级者确定了所有入选眼睛中都存在玻璃疣（科恩的kappa为1.0）。在FAF图像上，科恩的kappa为0.71。在地形评估中，在颞区23例，鼻区40例，下区40例，上区42例中检出周围玻璃膜疣。在SD-OCT图像上，周围的玻璃疣在97.1％的情况下具有高反射芯，而其余玻璃疣的特征在于反射芯低。黄斑受23眼早期/中度AMD（43.5％）和6眼晚期AMD（60.5％）的影响。结论我们提供了有和没有AMD的眼部周围玻璃膜疣的综合多模态成像评估。周围性玻璃膜疣的特征在于可能提示这些病变构成一种独特的疾病，而不是代表AMD的扩展。